Investigation of the PABPC1-BTG2 interaction and its effects on mRNA deadenylation by CNOT7(CAF1)
Polyadenylation is the process of the addition of a poly(A) tail to the 3ʹ end of mRNA. The binding of human poly(A) binding protein to the poly(A) tail can either initiate or repress translation or regulate mRNA degradation. Cytoplasmic mRNA degradation in eukaryotes involves shortening of mRNA pol...
| Main Author: | Ameerul Moominin, Aalam Mohammed |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/68944/ |
Similar Items
Biochemical analysis of the BTG1 variants associated with Non-Hodgkin’s lymphoma
by: Almasmoum, Hibah
Published: (2017)
by: Almasmoum, Hibah
Published: (2017)
Reconstitution of the Core Ccr4-Not Complex and Evidence for Possible Interaction between YTHDF2 and Human CNOT9
by: Gong, Yutong
Published: (2025)
by: Gong, Yutong
Published: (2025)
Tying the CNOT: CNOT1 regulates poly(A) tail length at the end and the beginning
by: Williams, Kathryn
Published: (2021)
by: Williams, Kathryn
Published: (2021)
The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module
by: Maryati, Marayti, et al.
Published: (2015)
by: Maryati, Marayti, et al.
Published: (2015)
Characterisation and Intercellular Mechanistic Analysis of Supramolecular, Cationic, mRNA-Loaded Polyplexes for Efficient Transfection in HEK293T and A549 Cells
by: Smith, Silvia
Published: (2023)
by: Smith, Silvia
Published: (2023)
Molecular biology approaches to quantify subcellular localisation of mRNA therapeutics
by: Smart, Alfredo D.
Published: (2025)
by: Smart, Alfredo D.
Published: (2025)
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes
by: Doidge, Rachel L.
Published: (2013)
by: Doidge, Rachel L.
Published: (2013)
Part A: RNA Therapeutics. Development and challenges in nanoparticle delivery/ Part B: Synthesis and characterisation of supramolecular polyplexes for mRNA delivery
by: Vasudevan, Akshaya
Published: (2024)
by: Vasudevan, Akshaya
Published: (2024)
The dynamic role of mRNA m6A methylation in Arabidopsis thaliana and Solanum lycopersicum
by: Chak, Samuel Erwin Seng Chung
Published: (2024)
by: Chak, Samuel Erwin Seng Chung
Published: (2024)
Sugar-coated nanoparticles: Investigating lipid-terminated glycopolymers for targeted nanoparticle delivery of nucleic acids
by: Fiedler, Benjamin
Published: (2024)
by: Fiedler, Benjamin
Published: (2024)
Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI
by: Růžička, Kamil, et al.
Published: (2017)
by: Růžička, Kamil, et al.
Published: (2017)
1-Hydroxy-xanthine Inhibitors of Caf1 Deadenylase as a Potential Treatment for Osteoporosis
by: Ziemann, Max
Published: (2019)
by: Ziemann, Max
Published: (2019)
A non-proteolytic role for ubiquitin in deadenylation by the RNA-binding E3 ligase MEX-3C
by: Cano, Florencia, et al.
Published: (2015)
by: Cano, Florencia, et al.
Published: (2015)
Analysis of the Ccr4-Not deadenylase complex: a biochemical and computational approach
by: Balacco, Dario Leonardo
Published: (2017)
by: Balacco, Dario Leonardo
Published: (2017)
Exploring the biological functions of vtRNA 1-1
by: Wainwright, Thomas
Published: (2023)
by: Wainwright, Thomas
Published: (2023)
Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation
by: Soukarieh, Fadi, et al.
Published: (2016)
by: Soukarieh, Fadi, et al.
Published: (2016)
Alternative RNA splicing: contribution to pain and potential therapeutic strategy
by: Donaldson, Lucy F., et al.
Published: (2016)
by: Donaldson, Lucy F., et al.
Published: (2016)
Correlation between HPV infection and human beta-defensin mRNA expression in pterygium and normal conjunctiva epithelial cells
by: Aliyu, Abubakar Saadatu
Published: (2017)
by: Aliyu, Abubakar Saadatu
Published: (2017)
m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
by: Haussmann, Irmgard U., et al.
Published: (2016)
by: Haussmann, Irmgard U., et al.
Published: (2016)
Calpain proteinase mRNA and beta-agonist induced muscle growth
by: Parr, Timothy
Published: (1991)
by: Parr, Timothy
Published: (1991)
Investigating the role of eIF4A2 in the spatial regulation of metabolic adaptation to hypoxia in colorectal cancer
by: Thornton, Luke
Published: (2023)
by: Thornton, Luke
Published: (2023)
Synthesis and Advanced Characterisation of Nanoparticle Gene Delivery Systems for mRNA therapeutics
by: Khosravi, Rahman
Published: (2025)
by: Khosravi, Rahman
Published: (2025)
Identifying potential RNA editing sites from RNA-Sequencing data from human brain tissue
by: North, Francesca Louise
Published: (2018)
by: North, Francesca Louise
Published: (2018)
ATNT: an enhanced system for expression of polycistronic secondary metabolite gene clusters in Aspergillus niger
by: Geib, Elena, et al.
Published: (2017)
by: Geib, Elena, et al.
Published: (2017)
Development of delayed ripening papaya (Carica papaya L.) CV. 'eksotika' using RNA interference and antisense technologies
by: Sekeli, Rogayah
Published: (2013)
by: Sekeli, Rogayah
Published: (2013)
Characterization of miR-3099-mediated posttranscriptional of target genes regulation during neurogenesis in mice
by: Zainal Abidin, Shahidee
Published: (2019)
by: Zainal Abidin, Shahidee
Published: (2019)
Pollutants Inflow from Btg Ai River and Delok River and Btg Ai Reservoir Outflow and Possible Impact on Aquaculture
by: Wong, Yik Men
Published: (2012)
by: Wong, Yik Men
Published: (2012)
Optimization Of RNA Extraction And Generation Of Expressed Sequence Tags From Sargassum Binderi (Sonder) J. Agardh
by: Wong, Tony Kok Min
Published: (2005)
by: Wong, Tony Kok Min
Published: (2005)
Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors
by: Muthukaruppan, Anita, et al.
Published: (2017)
by: Muthukaruppan, Anita, et al.
Published: (2017)
Binding interactions of the mRNA regulator CELF1
by: Edwards, John Michael
Published: (2013)
by: Edwards, John Michael
Published: (2013)
MicroRNA Regulation in the Inflammatory Response
by: Martin, Athena
Published: (2023)
by: Martin, Athena
Published: (2023)
RNA interference therapeutics for cancer: challenges and opportunities
by: Bora, R., et al.
Published: (2012)
by: Bora, R., et al.
Published: (2012)
The role of the CBLL1/HAKAI E3 Ubiquitin Ligase component and its association with the RNA methyltransferase complex in breast cancer
by: Thompson, Rachel
Published: (2025)
by: Thompson, Rachel
Published: (2025)
Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs
by: Dhir, Ashish, et al.
Published: (2015)
by: Dhir, Ashish, et al.
Published: (2015)
Development of a stable T7 RNA polymerase expressing cell line using a lentivirus system
by: Yeong, Ming Yue
Published: (2019)
by: Yeong, Ming Yue
Published: (2019)
Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency
by: Capel, Victoria, et al.
Published: (2016)
by: Capel, Victoria, et al.
Published: (2016)
Mechanisms and roles of FLYWCH1 in colorectal cancer
by: Onyido, Emenike K.
Published: (2017)
by: Onyido, Emenike K.
Published: (2017)
Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection
by: Cong, Wei, et al.
Published: (2017)
by: Cong, Wei, et al.
Published: (2017)
Evidence for an ancient aquatic origin of the RNA viral order Articulavirales
by: Petrone, M.E., et al.
Published: (2023)
by: Petrone, M.E., et al.
Published: (2023)
Purification of enzyme and influence of substrate specificity on â-1,6-glucanase gene expression in Trichoderma harzianum
by: Mustafa, Muskhazli, et al.
Published: (2009)
by: Mustafa, Muskhazli, et al.
Published: (2009)
Similar Items
-
Biochemical analysis of the BTG1 variants associated with Non-Hodgkin’s lymphoma
by: Almasmoum, Hibah
Published: (2017) -
Reconstitution of the Core Ccr4-Not Complex and Evidence for Possible Interaction between YTHDF2 and Human CNOT9
by: Gong, Yutong
Published: (2025) -
Tying the CNOT: CNOT1 regulates poly(A) tail length at the end and the beginning
by: Williams, Kathryn
Published: (2021) -
The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module
by: Maryati, Marayti, et al.
Published: (2015) -
Characterisation and Intercellular Mechanistic Analysis of Supramolecular, Cationic, mRNA-Loaded Polyplexes for Efficient Transfection in HEK293T and A549 Cells
by: Smith, Silvia
Published: (2023)