Histopathological characterisation of colitis in Western lowland gorillas (Gorilla gorilla ssp. gorilla)
In captive gorillas, ulcerative colitis is an important cause of morbidity and mortality with no established definite aetiopathogenesis. The aim of the study was to histopathologically characterise colon lesions in captive western lowland gorillas (Gorilla gorilla ssp. gorilla) and to investigate th...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2022
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| Online Access: | https://eprints.nottingham.ac.uk/68425/ |
| _version_ | 1848800486798393344 |
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| author | Morey Matamalas, Antonia |
| author_facet | Morey Matamalas, Antonia |
| author_sort | Morey Matamalas, Antonia |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In captive gorillas, ulcerative colitis is an important cause of morbidity and mortality with no established definite aetiopathogenesis. The aim of the study was to histopathologically characterise colon lesions in captive western lowland gorillas (Gorilla gorilla ssp. gorilla) and to investigate the feasibility of applying the Nancy index, a disease activity scoring system for ulcerative colitis in humans. Colon samples from 21 animals were evaluated based on histopathological characteristics for the diagnosis of inflammatory bowel disease (IBD) in humans and divided into acute and chronic changes. The Nancy index, graded 0 to 4, was applied to all cases. Special stains including Ziehl-Neelsen, Warthin-Starry, Gram and Periodic Acid Schiff reaction were used to identify potential aetiological agents. Most common acute changes included neutrophils in the lamina propria (17/18, 94%), mucosal and submucosal oedema (12/18, 67%), and crypt abscesses (8/18, 44%). Most common chronic changes were lamina proprial lymphoplasmacytic infiltrates (17/18, 94%) and crypt dilation/distortion (6/18, 33%). Based on the Nancy index, 4/21 (19%) cases were graded as grade 4 (the highest grade), 2/21 (10%) were identified as grade 3, 11/21 (52%) grade 2, and 4/21 (19%) cases were graded 0. The changes in the colon observed in our study show comparable characteristics to the acute phase of ulcerative colitis described in humans. No unifying aetiopathogenesis could be identified. The Nancy index proved a valuable tool for the standardisation of disease activity grading and comparison for further studies in gorilla colitis. |
| first_indexed | 2025-11-14T20:52:20Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-68425 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:52:20Z |
| publishDate | 2022 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-684252025-02-28T15:14:44Z https://eprints.nottingham.ac.uk/68425/ Histopathological characterisation of colitis in Western lowland gorillas (Gorilla gorilla ssp. gorilla) Morey Matamalas, Antonia In captive gorillas, ulcerative colitis is an important cause of morbidity and mortality with no established definite aetiopathogenesis. The aim of the study was to histopathologically characterise colon lesions in captive western lowland gorillas (Gorilla gorilla ssp. gorilla) and to investigate the feasibility of applying the Nancy index, a disease activity scoring system for ulcerative colitis in humans. Colon samples from 21 animals were evaluated based on histopathological characteristics for the diagnosis of inflammatory bowel disease (IBD) in humans and divided into acute and chronic changes. The Nancy index, graded 0 to 4, was applied to all cases. Special stains including Ziehl-Neelsen, Warthin-Starry, Gram and Periodic Acid Schiff reaction were used to identify potential aetiological agents. Most common acute changes included neutrophils in the lamina propria (17/18, 94%), mucosal and submucosal oedema (12/18, 67%), and crypt abscesses (8/18, 44%). Most common chronic changes were lamina proprial lymphoplasmacytic infiltrates (17/18, 94%) and crypt dilation/distortion (6/18, 33%). Based on the Nancy index, 4/21 (19%) cases were graded as grade 4 (the highest grade), 2/21 (10%) were identified as grade 3, 11/21 (52%) grade 2, and 4/21 (19%) cases were graded 0. The changes in the colon observed in our study show comparable characteristics to the acute phase of ulcerative colitis described in humans. No unifying aetiopathogenesis could be identified. The Nancy index proved a valuable tool for the standardisation of disease activity grading and comparison for further studies in gorilla colitis. 2022-07-31 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/68425/1/MVM%20THESIS%20Research_Corrections3_clean%20version.pdf Morey Matamalas, Antonia (2022) Histopathological characterisation of colitis in Western lowland gorillas (Gorilla gorilla ssp. gorilla). MVM thesis, University of Nottingham. gorillas primate diseases ulcerative colitis Nancy index |
| spellingShingle | gorillas primate diseases ulcerative colitis Nancy index Morey Matamalas, Antonia Histopathological characterisation of colitis in Western lowland gorillas (Gorilla gorilla ssp. gorilla) |
| title | Histopathological characterisation of colitis in Western lowland gorillas (Gorilla gorilla ssp. gorilla) |
| title_full | Histopathological characterisation of colitis in Western lowland gorillas (Gorilla gorilla ssp. gorilla) |
| title_fullStr | Histopathological characterisation of colitis in Western lowland gorillas (Gorilla gorilla ssp. gorilla) |
| title_full_unstemmed | Histopathological characterisation of colitis in Western lowland gorillas (Gorilla gorilla ssp. gorilla) |
| title_short | Histopathological characterisation of colitis in Western lowland gorillas (Gorilla gorilla ssp. gorilla) |
| title_sort | histopathological characterisation of colitis in western lowland gorillas (gorilla gorilla ssp. gorilla) |
| topic | gorillas primate diseases ulcerative colitis Nancy index |
| url | https://eprints.nottingham.ac.uk/68425/ |