The study of troglitazone liver toxicity via in vitro and in silico approaches
Background: Drug-induced liver injury (DILI) is rare but potentially lethal, and it can cause liver disease attributable to all types of drugs. The adverse impact of most of the DILI incidents is mild, and it recovers after the removal of drugs. The harmful agents should be identified and removed as...
| Main Author: | Nuamah, M.F |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/68294/ |
Similar Items
Biomarkers of drug-induced liver injury
by: Atallah, Edmond
Published: (2024)
by: Atallah, Edmond
Published: (2024)
Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications
by: Kaliyaperumal, Kalaiyarasi, et al.
Published: (2018)
by: Kaliyaperumal, Kalaiyarasi, et al.
Published: (2018)
Hepatoprotective effect of Muntingia calabura L. Leaf extracts
by: Mahmood, Nur Diyana
Published: (2016)
by: Mahmood, Nur Diyana
Published: (2016)
Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury
by: Carter, Wayne, et al.
Published: (2016)
by: Carter, Wayne, et al.
Published: (2016)
Minocycline hepatotoxicity: clinical characterization and identification of HLA-B∗ 35:02 as a risk factor
by: Urban, Thomas Jacob, et al.
Published: (2017)
by: Urban, Thomas Jacob, et al.
Published: (2017)
The effect of circulatory dysfunction upon the liver in haemodialysis patients
by: Grant, Claire
Published: (2019)
by: Grant, Claire
Published: (2019)
The histomorphological analysis of liver following administration of low doses of diclofenac and ibuprofen
by: Mohanambal, Moorthy, et al.
Published: (2009)
by: Mohanambal, Moorthy, et al.
Published: (2009)
Antiproliferative effects of zerumbone-hydroxypropyl-ß-cyclodextrin inclusion complex on HepG2 liver cancer cells in vitro
by: Muhammad Nadzri, Nabilah
Published: (2013)
by: Muhammad Nadzri, Nabilah
Published: (2013)
Biomarkers to predict advanced liver diseases
by: Alenezi, Yusef
Published: (2024)
by: Alenezi, Yusef
Published: (2024)
Deciphering the role of BMP4 signalling and gene regulation in the specification of human liver progenitor cells
by: Durczak, Paulina Maria
Published: (2023)
by: Durczak, Paulina Maria
Published: (2023)
The identification of chronic liver disease in primary care using non-invasive diagnostics within a novel pathway
by: Harman, David J.
Published: (2017)
by: Harman, David J.
Published: (2017)
Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection
by: He, Jun-Jun, et al.
Published: (2016)
by: He, Jun-Jun, et al.
Published: (2016)
From semi-synthetic to natural biomaterials: a journey to the development of an optimized in-vitro model for liver tissue engineering
by: Tarsitano, Elisa
Published: (2022)
by: Tarsitano, Elisa
Published: (2022)
Increased liver fat and glycogen stores after consumption
of high versus low glycaemic index food: a randomized
crossover study
by: Bawden, Stephen, et al.
Published: (2016)
by: Bawden, Stephen, et al.
Published: (2016)
Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses
by: Tirnitz-Parker, Nina, et al.
Published: (2014)
by: Tirnitz-Parker, Nina, et al.
Published: (2014)
Liver segmentation on CT images using random walkers and fuzzy c-means for treatment planning and monitoring of tumors in liver cancer patients
by: Moghbel, Mehrdad
Published: (2017)
by: Moghbel, Mehrdad
Published: (2017)
Microsphere distribution and radiation dosimetry in human liver following Yttrium-90 microsphere therapy.
by: Campbell, Andrew M.
Published: (2000)
by: Campbell, Andrew M.
Published: (2000)
Detection of liver injury in IBD using Transient Elastography
by: Thin, L., et al.
Published: (2014)
by: Thin, L., et al.
Published: (2014)
Campylobacters and their bacteriophages from chicken liver: the prospect for phage biocontrol
by: Firlieyanti, Antung S., et al.
Published: (2016)
by: Firlieyanti, Antung S., et al.
Published: (2016)
Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly?
by: Ratib, Sonia, et al.
Published: (2017)
by: Ratib, Sonia, et al.
Published: (2017)
The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity
by: Fakurazi, Sharida, et al.
Published: (2008)
by: Fakurazi, Sharida, et al.
Published: (2008)
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
by: Thabet, Khaled, et al.
Published: (2016)
by: Thabet, Khaled, et al.
Published: (2016)
Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models
by: Maeda, H., et al.
Published: (2015)
by: Maeda, H., et al.
Published: (2015)
Characterization and cytotoxicity of clausenidin from Clausena excavata Burm f. and its effects on cell cycle regulation and apoptosis of liver (hepg2) and colon (ht29) cancer cell lines
by: Waziri, Peter Maitalata
Published: (2017)
by: Waziri, Peter Maitalata
Published: (2017)
Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography
by: Harman, David J., et al.
Published: (2018)
by: Harman, David J., et al.
Published: (2018)
Risk stratification of chronic liver disease in the community
by: Harris, Rebecca
Published: (2019)
by: Harris, Rebecca
Published: (2019)
Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review
by: Harris, Rebecca, et al.
Published: (2017)
by: Harris, Rebecca, et al.
Published: (2017)
Lower Fructose Intake May Help Protect Against Development of Nonalcoholic Fatty Liver in Adolescents With Obesity
by: O'Sullivan, T., et al.
Published: (2014)
by: O'Sullivan, T., et al.
Published: (2014)
The role of intramyocellular lipid content in the physiological changes observed in inactivity, exercise, and non-alcoholic fatty liver disease
by: Chivaka, Prince
Published: (2023)
by: Chivaka, Prince
Published: (2023)
Effects of CXCR4 Silencing by Sirna Engrafted Cotionized Dextran in Mouse Models of Colorectal Cancer and Liver Metastasis
by: Abedini, Fatemeh
Published: (2011)
by: Abedini, Fatemeh
Published: (2011)
Potential chemoprevention of primary liver cancer using optimized formulation of Strobilanthus crispus (L.) blume and Centella asiatica L. juices
by: Hussin, Faridah
Published: (2011)
by: Hussin, Faridah
Published: (2011)
Acute toxicity of Trigonella foenum-graecum (Fenugreek) seeds aqueous extracton liver in male mice, histopathological study
by: Hamad Alfarisi, Hamad Abdulsalam, et al.
Published: (2017)
by: Hamad Alfarisi, Hamad Abdulsalam, et al.
Published: (2017)
Modelling non-alcoholic fatty liver disease (NAFLD) using human induced pluripotent stem cell (hiPSC)-derived hepatocytes
by: Lo, Peggy Cho Kiu
Published: (2022)
by: Lo, Peggy Cho Kiu
Published: (2022)
Cholesteryl ester transfer protein gene ploymorphisms increase the risk of fatty liver in females independent of adisposity
by: Adams, L., et al.
Published: (2012)
by: Adams, L., et al.
Published: (2012)
Liver progenitor cell interactions with the extracellular matrix
by: Zhu, C., et al.
Published: (2012)
by: Zhu, C., et al.
Published: (2012)
Evaluating human induced pluripotent stem cell-derived cardiomyocytes for commercial drug testing
by: Katili, Puspita Anggraini
Published: (2020)
by: Katili, Puspita Anggraini
Published: (2020)
Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China
by: Tian, A.L., et al.
Published: (2017)
by: Tian, A.L., et al.
Published: (2017)
In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver
by: Drake, Amanda J., et al.
Published: (2015)
by: Drake, Amanda J., et al.
Published: (2015)
Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study
by: Nicoletti, Paola, et al.
Published: (2016)
by: Nicoletti, Paola, et al.
Published: (2016)
Morphological changes in liver cells of hypercholesterolaemic-induced rats and hepG2 cell lines associated with edible bird’s nest supplementation
by: Mohd Noor, Mohd Akmal
Published: (2020)
by: Mohd Noor, Mohd Akmal
Published: (2020)
Similar Items
-
Biomarkers of drug-induced liver injury
by: Atallah, Edmond
Published: (2024) -
Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications
by: Kaliyaperumal, Kalaiyarasi, et al.
Published: (2018) -
Hepatoprotective effect of Muntingia calabura L. Leaf extracts
by: Mahmood, Nur Diyana
Published: (2016) -
Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury
by: Carter, Wayne, et al.
Published: (2016) -
Minocycline hepatotoxicity: clinical characterization and identification of HLA-B∗ 35:02 as a risk factor
by: Urban, Thomas Jacob, et al.
Published: (2017)