Biophysical studies of ligand selectivity for the hATG8 family of autophagy proteins
Selective autophagy is a process by which potentially toxic material such as aggregated proteins, organelles and pathogens are specifically targeted and transported to autophagosomes and subsequent degradation by the lysosome. The process relies on selective autophagy receptor proteins (SARs) recogn...
| Main Author: | Butler, Kevin |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2021
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/66737/ |
Similar Items
Investigating a key autophagy protein-protein interaction and its modulation by phosphorylation and an ALS-related mutation
by: Brennan, Andrew
Published: (2019)
by: Brennan, Andrew
Published: (2019)
Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD
by: Goode, Alice, et al.
Published: (2016)
by: Goode, Alice, et al.
Published: (2016)
The role of survivin in autophagy
by: Humphry, Nicola
Published: (2018)
by: Humphry, Nicola
Published: (2018)
Structural and biophysical investigations into ubiquitin binding proteins
by: Garner, Thomas Peter
Published: (2011)
by: Garner, Thomas Peter
Published: (2011)
Molecular simulation of protein-ligand complexes
by: Guest, Ellen
Published: (2022)
by: Guest, Ellen
Published: (2022)
Autophagy, citrullination and cancer
by: Durrant, LG
Published: (2016)
by: Durrant, LG
Published: (2016)
Metabolic stress and cancer: is autophagy the common denominator and a feasible target?
by: Giuliani, C., et al.
Published: (2014)
by: Giuliani, C., et al.
Published: (2014)
Modelling the influence of ligand binding towards the structure and dynamics of protein arginine deiminase IV
by: Ibrahim, Zalikha
Published: (2017)
by: Ibrahim, Zalikha
Published: (2017)
Connecting MicroRNA and autophagy disturbances in Amyotrophic Lateral Sclerosis (ALS)
by: Foggin, Sophie
Published: (2022)
by: Foggin, Sophie
Published: (2022)
Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes?
by: Tacar, O., et al.
Published: (2013)
by: Tacar, O., et al.
Published: (2013)
Induction of autophagy by non-structural protein 6 in important animal and human coronaviruses
by: Daubrah-Scott, Tyler-Josh
Published: (2025)
by: Daubrah-Scott, Tyler-Josh
Published: (2025)
Bayesian optimization of large-scale biophysical networks
by: Hadida, Jonathan, et al.
Published: (2018)
by: Hadida, Jonathan, et al.
Published: (2018)
Role of quantum chemical calculations in molecular biophysics with a historical perspective
by: Kukushkin, A., et al.
Published: (2009)
by: Kukushkin, A., et al.
Published: (2009)
The effects of a short-term (1-week) very low-calorie diet (850 calories) comparing low and normal protein content on cardiometabolic outcomes, glucose metabolism and autophagy
by: Burns, Lucy
Published: (2025)
by: Burns, Lucy
Published: (2025)
Combinatorial application of tocotrienols and chemotherapeutic drugs enhances apoptosis and autophagy in colorectal cancer cells
by: Tham, Shiau Ying
Published: (2020)
by: Tham, Shiau Ying
Published: (2020)
Measuring ligand concentration where it matters: Assessing the “micro pharmacokinetic/pharmacodynamics” of adenosine receptor ligands
by: Lochray, Jack
Published: (2022)
by: Lochray, Jack
Published: (2022)
Sterically demanding pincer ligands for transition metal chemistry
by: Albelwe, Bayan L.
Published: (2025)
by: Albelwe, Bayan L.
Published: (2025)
Docking and molecular dynamics simulations of the ternary complex nisin2:lipid II
by: Mulholland, Sam, et al.
Published: (2016)
by: Mulholland, Sam, et al.
Published: (2016)
Synthesis, characterization, and bioactivities of dithiocarbazate-Schiff base ligands and their metal complexes
by: Low, May Lee
Published: (2014)
by: Low, May Lee
Published: (2014)
Alkaline earth complexes of a sterically demanding guanidinate ligand
by: Moxey, Graeme J., et al.
Published: (2015)
by: Moxey, Graeme J., et al.
Published: (2015)
Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacological modulation
by: Orfali, Nina, et al.
Published: (2015)
by: Orfali, Nina, et al.
Published: (2015)
Geometric adventures with self-assembled metal-ligand coordination structures
by: Fan, Yucong
Published: (2024)
by: Fan, Yucong
Published: (2024)
Biphasic effects of autophagy on decompression bubble-induced endothelial injury
by: Wang, M., et al.
Published: (2019)
by: Wang, M., et al.
Published: (2019)
Including Tightly-Bound Water Molecules in de Novo Drug Design. Exemplification through the in Silico Generation of Poly(ADP-ribose)polymerase Ligands
by: Mancera, Ricardo, et al.
Published: (2005)
by: Mancera, Ricardo, et al.
Published: (2005)
Defective recognition of ATG8/LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD
by: Goode, Alice, et al.
Published: (2016)
by: Goode, Alice, et al.
Published: (2016)
The impact of manipulating angle of projection and height of release on accuracy in the netball free throw / Siti Haslina Puteh
by: Puteh, Siti Haslina
Published: (2019)
by: Puteh, Siti Haslina
Published: (2019)
X-ray photoelectron spectroscopy as a probe of rhodium-ligand interaction in ionic liquids
by: Men, Shuan, et al.
Published: (2016)
by: Men, Shuan, et al.
Published: (2016)
Synthesis and Complexation of a Bulky Silyl Phosphanide and Extended PNNNP Carbazole-based Ligand
by: Churchill, Olivia
Published: (2024)
by: Churchill, Olivia
Published: (2024)
Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole
by: Mazlan, Nurul Ain
Published: (2014)
by: Mazlan, Nurul Ain
Published: (2014)
Characterisation of autophagosomes as a source of novel citrullinated antigens for use as a cancer vaccine
by: Heath, Bryony
Published: (2023)
by: Heath, Bryony
Published: (2023)
Identification of a Cyanine-dye labeled peptidic ligand for Y₁R and Y₄R, based upon the Neuropeptide Y C-terminal analogue, BVD-15
by: Liu, Mengjie, et al.
Published: (2016)
by: Liu, Mengjie, et al.
Published: (2016)
N/P-based Sterically Demanding Ligands: Synthesis, Reactivity and Catalysis
by: Nolla Saltiel, Roberto
Published: (2019)
by: Nolla Saltiel, Roberto
Published: (2019)
Synthesis, characterization and bioactivity of mixed-ligandCu(II) complexes containing Schiff bases derived fromS-benzyldithiocarbazate and saccharinate ligand and the X-raycrystal structure of the copper-saccharinate complex containing S-benzyl-b-N-(Synthesis, characterization and bioactivity of mixed-ligandCu(II) complexes containing Schiff bases derived fromS-benzyldithiocarbazate and saccharinate ligand and the X-raycrystal structure of the copper-saccharinate complex containing S-benzyl-b-N-(acet).
by: Crouse, Karen Anne, et al.
Published: (2007)
by: Crouse, Karen Anne, et al.
Published: (2007)
Biophysical investigations of the mechanism of colicin translocation
by: Hands, Sarah Louise
Published: (2005)
by: Hands, Sarah Louise
Published: (2005)
Hetero-Ligand peptide functionalization of gold nanoparticles for selective detection of cobalt (II) ions
by: Jamadon, Nur Khaliesah
Published: (2022)
by: Jamadon, Nur Khaliesah
Published: (2022)
Optimisation of Peptide Linker-based Fluorescent Ligands for the Histamine H1 Receptor
by: Kok, Zhi Yuan
Published: (2020)
by: Kok, Zhi Yuan
Published: (2020)
Discovering the molecular basis for ligand pharmacological activity on β-adrenoceptors
by: Bunsuz, Asuman
Published: (2023)
by: Bunsuz, Asuman
Published: (2023)
Investigating ligand-directed signalling at the cannabinoid receptor 2
by: Hourani, Wafa
Published: (2019)
by: Hourani, Wafa
Published: (2019)
Theoretical evaluation of wall teichoic acids in the cavitation-mediated pores formation in Gram-positive bacteria subjected to an electric field
by: Rauch, Cyril, et al.
Published: (2014)
by: Rauch, Cyril, et al.
Published: (2014)
Investigating the molecular basis of biased signalling at cannabinoid receptors
by: Dennis, Morgan Jane
Published: (2023)
by: Dennis, Morgan Jane
Published: (2023)
Similar Items
-
Investigating a key autophagy protein-protein interaction and its modulation by phosphorylation and an ALS-related mutation
by: Brennan, Andrew
Published: (2019) -
Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD
by: Goode, Alice, et al.
Published: (2016) -
The role of survivin in autophagy
by: Humphry, Nicola
Published: (2018) -
Structural and biophysical investigations into ubiquitin binding proteins
by: Garner, Thomas Peter
Published: (2011) -
Molecular simulation of protein-ligand complexes
by: Guest, Ellen
Published: (2022)