Synthesis and biological evaluation of novel PqsR antagonists to combat Pseudomonas aeruginosa infections

QR Code

Synthesis and biological evaluation of novel PqsR antagonists to combat Pseudomonas aeruginosa infections

Pseudomonas aeruginosa is an important opportunistic pathogen that belongs to superbug microorganisms and shows an increased number of multi-drug resistant (MDR) clinical isolates. P. aeruginosa has three hierarchically organised quorum sensing (QS) or cell to cell communication systems named las, r...

Full description

Bibliographic Details
Main Author:	Mashabi, Alaa
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2021
Subjects:	Novel PqsR antagonists Pseudomonas aeruginosa infections
Online Access:	https://eprints.nottingham.ac.uk/65941/

Similar Items

Design, synthesis, and biological evaluation of PqsR antagonists guided by classic hit-to- lead optimisation process and fragment- based methods for the treatment of Pseudomonas aeruginosa infections
by: Liu, Ruiling
Published: (2021)

Synthesis and biological evaluation of novel PqsR antagonists to combat Pseudomonas aeruginosa infections
by: Mashabi, Alaa
Published: (2021)

Structural investigation of Pseudomonas aeruginosa quorum sensing receptor PqsR to aid virulence inhibition
by: Richardson, William
Published: (2022)

New approaches to detect and inhibit quorum sensing activity in Pseudomonas aeruginosa
by: Lafayette, I. H. G.
Published: (2016)

In silico and in vitro-guided identification of inhibitors of alkylquinolone-dependent quorum sensing in Pseudomonas aeruginosa
by: Soukarieh, Fadi, et al.
Published: (2018)

Crystal structure of Pseudomonas aeruginosa condensing enzyme PqsBC
by: Prasetya, Fajar
Published: (2018)

New insights into the repressor role of PqsE over pqsA
by: Romo Catalán, Natalia Valentina
Published: (2022)

Pseudomonas aeruginosa PQS mediated virulence regulation and interference
by: Vico-Oton, Eduard
Published: (2019)

Post-transcriptional regulation of the Pqs Quorum Sensing System in Pseudomonas aeruginosa
by: Panagiotopoulou, Dimitra
Published: (2024)

Prevalence of metallo-Beta-lactamase producing Pseudomonas aeruginosa in a tertiary care at Hospital Kuala Lumpur, Malaysia
by: Idris, Siti Nur Atiqah
Published: (2016)

Biosurfactant Production by Pseudomonas Aeruginosa 181
by: Yassin Al-Araji, Laith Issa
Published: (2004)

In vitro study of effects of antibiotics on Pseudomonas aeruginosa biofilm formation
by: Jeevajothi Nathan, Priadarssini
Published: (2017)

An ex vivo lung model to study bronchioles infected with Pseudomonas aeruginosa biofilms
by: Harrison, Freya, et al.
Published: (2016)

Production and characterization of biosurfactant by isolated Pseudomonas aeruginosa RS6 strain
by: Nordin, Nordiyana
Published: (2016)

PQS-dependent quorum sensing in pseudomonas aeruginosa is linked to protein export via the twin-arginine translocation (tat) system
by: Smith, Frances
Published: (2022)

Lectin-mediated biofilm maturation, quorum sensing and Pseudomonas aeruginosa infections in cystic fibrosis
by: Crusz, S.A.
Published: (2009)

Characterization of an Organic Solvent-Tolerant Protease from Pseudomonas Aeruginosa Strain K
by: Lee, Poh Geok
Published: (2003)

Production of biosurfactant from biodiesel side-stream glycerine by Pseudomonas aeruginosa RS6
by: Baskaran, Shobanah Menon
Published: (2020)

Role of lectin receptors in recognition of Pseudomonas aeruginosa biofilms
by: Almuhanna, Yasir Saleh I
Published: (2021)

SadB is a Pseudomonas aeruginosa global regulator
by: Papangeli, Maria
Published: (2022)

Search for Pseudomonas aeruginosa immune-modulatory but non-inducing agents
by: Jadhav, Gopal P.
Published: (2008)

Antimicrobial and anti-quorum sensing activties of javanese turmeric (Curcuma xanthorrhiza Roxb.) ethanolic extract against Pseudomonas aeruginosa
by: Othman, Ahmad Fiqri Mustaqim
Published: (2018)

Understanding the contribution of Resistance-Nodulation-Division family efflux pumps to the lifestyle of Pseudomonas aeruginosa
by: Scales, Danielle
Published: (2023)

Metabolic functions of the Pseudomonas aeruginosa aminoglycoside resistance gene, aph
by: Aksoy, Cemile Selin
Published: (2024)

Riboregulation in Pseudomonas aeruginosa
by: Silistre, Hazel
Published: (2016)

Exploring the structure, regulation, and function of the surface tethered Pseudomonas aeruginosa virulence factor, AaaA, and its role in maintaining chronic wound infections
by: Laxton, Claire. S.
Published: (2023)

Novel approaches to tackling antimicrobial resistance: the design, synthesis and evaluation of quorum sensing inhibitors in Pseudomonas aeruginosa
by: Grossman, Scott
Published: (2022)

Production of rhamnolipid biosurfactant by Pseudomonas aeruginosa using sludge palm oil as carbon source in stirred tank bioreactor
by: Yaacob, Nadhirah
Published: (2019)

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
by: Langton Hewer, Simon C., et al.
Published: (2014)

Pseudomonas aeruginosa: host interactions and the identification of novel modulators of quorum sensing-mediated virulence
by: Bates, Robyn Hannah
Published: (2014)

Linking fatty acid derivatives with signalling and cross-talk in Pseudomonas aeruginosa
by: Palenzuela Bretones, Diana
Published: (2017)

Root colonization and induction of pathogenesis-related genes by Pseudomonas aeruginosa strain UPMP3 in oil palm
by: Hamid, Sathyapriya
Published: (2012)

The role of C-type lectin receptors in the recognition of Pseudiminas aeruginosa
by: Alshahrani, Mohammad
Published: (2018)

Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis
by: Hurley, M.N., et al.
Published: (2012)

Surviving and thriving in the cystic fibrosis lung: contribution of an arginine specific aminopeptidase to sustained infection by Pseudomonas aeruginosa
by: Spencer, Daniella Lucy
Published: (2019)

Mitigating the harm caused by Pseudomonas aeruginosa in Cystic Fibrosis
by: Palser, Sally C.
Published: (2024)

Biodegradation of sodium dodecyl sulphate using locally isolated Pseudomonas aerugínosa sp. strain D1
by: Mahamood, Mazurin
Published: (2012)

Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR)
by: Ilangovan, Aravindan, et al.
Published: (2013)

In vitro combinatory antimicrobial effect of crude bacteriocins from Pediococcus pentosaceus strains and selected antibiotics against Pseudomonas aeruginosa ATCC 10145
by: Suffian, Suffi Nurul Husna
Published: (2020)

Investigating microbial biofilms within washing machines: novel nanosensor technology enables insights into pH gradients of Pseudomonas aeruginosa biofilms
by: Hollmann, Birte
Published: (2021)