Mechanisms of retention of PEGylated recombinant human deoxyribonuclease i (rhDNase) in the lungs

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Mechanisms of retention of PEGylated recombinant human deoxyribonuclease i (rhDNase) in the lungs

Conjugation of recombinant human deoxyribonuclease I (rhDNase) to large (≥ 20 kDa) polyethylene glycol (PEG) has been shown to prolong the lung residence time of the enzyme in mice. Here, we investigated the mechanisms of this extended retention of PEG-rhDNase conjugates. PEG-rhDNase conjugates...

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Bibliographic Details
Main Author:	Mahri, Sohaib
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2021
Subjects:	Recombinant human deoxyribonuclease I protein PEGylation pulmonary drug delivery alveolar macrophages transport across Calu-3 diffusion in mucus biodistribution cystic fibrosis.
Online Access:	https://eprints.nottingham.ac.uk/65811/

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