Design, synthesis, and biological evaluation of PqsR antagonists guided by classic hit-to- lead optimisation process and fragment- based methods for the treatment of Pseudomonas aeruginosa infections

Design, synthesis, and biological evaluation of PqsR antagonists guided by classic hit-to- lead optimisation process and fragment- based methods for the treatment of Pseudomonas aeruginosa infections

Pseudomonas aeruginosa (P. aeruginosa) a nosocomial pathogen, has become a serious public health threat due to its high mortality rates and serious antibiotic resistance issue. The Pseudomonas quinolone signal (pqs) system of P. aeruginosa is essential in regulating the biosynthesis of virulence fa...

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Bibliographic Details
Main Author: Liu, Ruiling
Format: Thesis (University of Nottingham only)
Language:English
Published: 2021
Subjects:
Pseudomonas aeruginosa
transcriptional regulators
PqsR
infection control
Online Access:https://eprints.nottingham.ac.uk/65628/

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