Is feline lymphoma worth managing differently?
zone lymphoma). There are few reports that determine whether immunophenotype confers any prognostic value in cats. A number of other factors have been proposed by several studies however, many have only assessed specific types of lymphomas such as GI, nasal and CNS lymphomas, reporting variable sur...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2021
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| Online Access: | https://eprints.nottingham.ac.uk/65530/ |
| _version_ | 1848800238470430720 |
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| author | Aworinde, Anne Adesola |
| author_facet | Aworinde, Anne Adesola |
| author_sort | Aworinde, Anne Adesola |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | zone lymphoma). There are few reports that determine whether immunophenotype confers any prognostic value in cats. A number of other factors have been proposed by several studies however, many have only assessed specific types of lymphomas such as GI, nasal and CNS lymphomas, reporting variable survival rates.
The purpose of this study was to determine whether the immunophenotype of lymphoma as well as other variables (such as age, gender, neutering status, anatomical site, treatment or histological grade) could determine how long affected cats live with a view to determining whether any recommendations could be made regarding management of the disease. As part of this study, the proportion of cats with a laboratory diagnosis of lymphoma that are subtyped and the frequency of each anatomical location were determined. The levels of certainty of cytological diagnoses of lymphoma was also assessed.
Data for this study was obtained retrospectively from CVS group laboratory databases identifying cases diagnosed by cytology and histology between January 2014- January 2018. Following removal of exclusions, statistical analysis were performed on the remaining 1549 cases. Medical information was obtained via practice database search for the CVS-owned practices and for the non-CVS owned practice by way of questionnaire. These included lymphoma cases diagnosed by histology between February 2018 and January 2019. Data was collated in Microsoft Excel. Survival analyses were performed on a total of 140 cases that met the inclusion criteria.
The intestine was the most common anatomical location with the second most common anatomical location being the lymph nodes in the head and neck region. Diagnostic doubt was commonly expressed in cytology reports. Only a small minority of cases were immunophenotyped at initial clinicians requests (5.6%, n=87). None of the variables that were assessed proved to have any prognostic significance and in contrast to the dog, neither the B-cell nor T-cell immunophenotype influenced survival.
In summary, this study showed that immunophenotyping of feline lymphoma is seldom requested, posing a challenge both for its evaluation as a prognostic tool in large retrospective studies and potentially its future utilisation as a prognostic tool. Although the remaining variables that were assessed did not predict prognosis in this study, the relatively small numbers of treated cats in each category did not give sufficient statistical power and therefore prospective studies performed on large groups of affected cats would be required for further confirmation. |
| first_indexed | 2025-11-14T20:48:23Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-65530 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:48:23Z |
| publishDate | 2021 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-655302024-02-05T10:43:10Z https://eprints.nottingham.ac.uk/65530/ Is feline lymphoma worth managing differently? Aworinde, Anne Adesola zone lymphoma). There are few reports that determine whether immunophenotype confers any prognostic value in cats. A number of other factors have been proposed by several studies however, many have only assessed specific types of lymphomas such as GI, nasal and CNS lymphomas, reporting variable survival rates. The purpose of this study was to determine whether the immunophenotype of lymphoma as well as other variables (such as age, gender, neutering status, anatomical site, treatment or histological grade) could determine how long affected cats live with a view to determining whether any recommendations could be made regarding management of the disease. As part of this study, the proportion of cats with a laboratory diagnosis of lymphoma that are subtyped and the frequency of each anatomical location were determined. The levels of certainty of cytological diagnoses of lymphoma was also assessed. Data for this study was obtained retrospectively from CVS group laboratory databases identifying cases diagnosed by cytology and histology between January 2014- January 2018. Following removal of exclusions, statistical analysis were performed on the remaining 1549 cases. Medical information was obtained via practice database search for the CVS-owned practices and for the non-CVS owned practice by way of questionnaire. These included lymphoma cases diagnosed by histology between February 2018 and January 2019. Data was collated in Microsoft Excel. Survival analyses were performed on a total of 140 cases that met the inclusion criteria. The intestine was the most common anatomical location with the second most common anatomical location being the lymph nodes in the head and neck region. Diagnostic doubt was commonly expressed in cytology reports. Only a small minority of cases were immunophenotyped at initial clinicians requests (5.6%, n=87). None of the variables that were assessed proved to have any prognostic significance and in contrast to the dog, neither the B-cell nor T-cell immunophenotype influenced survival. In summary, this study showed that immunophenotyping of feline lymphoma is seldom requested, posing a challenge both for its evaluation as a prognostic tool in large retrospective studies and potentially its future utilisation as a prognostic tool. Although the remaining variables that were assessed did not predict prognosis in this study, the relatively small numbers of treated cats in each category did not give sufficient statistical power and therefore prospective studies performed on large groups of affected cats would be required for further confirmation. 2021-07-03 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/65530/1/Masters%20research%20project%20corrections%20version%20280521.pdf Aworinde, Anne Adesola (2021) Is feline lymphoma worth managing differently? MVM thesis, University of Nottingham. lymphoma cats diseases |
| spellingShingle | lymphoma cats diseases Aworinde, Anne Adesola Is feline lymphoma worth managing differently? |
| title | Is feline lymphoma worth managing differently? |
| title_full | Is feline lymphoma worth managing differently? |
| title_fullStr | Is feline lymphoma worth managing differently? |
| title_full_unstemmed | Is feline lymphoma worth managing differently? |
| title_short | Is feline lymphoma worth managing differently? |
| title_sort | is feline lymphoma worth managing differently? |
| topic | lymphoma cats diseases |
| url | https://eprints.nottingham.ac.uk/65530/ |