TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes
We previously developed TANTIGEN, a comprehensive online database cataloging more than 1000 T cell epitopes and HLA ligands from 292 tumor antigens. In TANTIGEN 2.0, we significantly expanded coverage in both immune response targets (T cell epitopes and HLA ligands) and tumor antigens. It catalogs 4...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central Ltd
2021
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/65316/ |
| _version_ | 1848800210832064512 |
|---|---|
| author | Zhang, Guanglan Chitkushev, Lou Olsen, Lars Rønn Keskin, Derin B. Brusic, Vladimir |
| author_facet | Zhang, Guanglan Chitkushev, Lou Olsen, Lars Rønn Keskin, Derin B. Brusic, Vladimir |
| author_sort | Zhang, Guanglan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We previously developed TANTIGEN, a comprehensive online database cataloging more than 1000 T cell epitopes and HLA ligands from 292 tumor antigens. In TANTIGEN 2.0, we significantly expanded coverage in both immune response targets (T cell epitopes and HLA ligands) and tumor antigens. It catalogs 4,296 antigen variants from 403 unique tumor antigens and more than 1500 T cell epitopes and HLA ligands. We also included neoantigens, a class of tumor antigens generated through mutations resulting in new amino acid sequences in tumor antigens. TANTIGEN 2.0 contains validated TCR sequences specific for cognate T cell epitopes and tumor antigen gene/mRNA/protein expression information in major human cancers extracted by Human Pathology Atlas. TANTIGEN 2.0 is a rich data resource for tumor antigens and their associated epitopes and neoepitopes. It hosts a set of tailored data analytics tools tightly integrated with the data to form meaningful analysis workflows. It is freely available at http://projects.met-hilab.org/tadb. |
| first_indexed | 2025-11-14T20:47:57Z |
| format | Article |
| id | nottingham-65316 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:47:57Z |
| publishDate | 2021 |
| publisher | BioMed Central Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-653162021-06-04T02:29:28Z https://eprints.nottingham.ac.uk/65316/ TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes Zhang, Guanglan Chitkushev, Lou Olsen, Lars Rønn Keskin, Derin B. Brusic, Vladimir We previously developed TANTIGEN, a comprehensive online database cataloging more than 1000 T cell epitopes and HLA ligands from 292 tumor antigens. In TANTIGEN 2.0, we significantly expanded coverage in both immune response targets (T cell epitopes and HLA ligands) and tumor antigens. It catalogs 4,296 antigen variants from 403 unique tumor antigens and more than 1500 T cell epitopes and HLA ligands. We also included neoantigens, a class of tumor antigens generated through mutations resulting in new amino acid sequences in tumor antigens. TANTIGEN 2.0 contains validated TCR sequences specific for cognate T cell epitopes and tumor antigen gene/mRNA/protein expression information in major human cancers extracted by Human Pathology Atlas. TANTIGEN 2.0 is a rich data resource for tumor antigens and their associated epitopes and neoepitopes. It hosts a set of tailored data analytics tools tightly integrated with the data to form meaningful analysis workflows. It is freely available at http://projects.met-hilab.org/tadb. BioMed Central Ltd 2021-04-14 Article PeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/65316/1/10.1186_s12859-021-03962-7.pdf Zhang, Guanglan, Chitkushev, Lou, Olsen, Lars Rønn, Keskin, Derin B. and Brusic, Vladimir (2021) TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes. BMC Bioinformatics, 22 (S8). ISSN 1471-2105 Cancer vaccine； Immunotherapy； Neoantigen； Neoepitope； T cell epitope prediction； Tumor antigen http://dx.doi.org/10.1186/s12859-021-03962-7 doi:10.1186/s12859-021-03962-7 doi:10.1186/s12859-021-03962-7 |
| spellingShingle | Cancer vaccine； Immunotherapy； Neoantigen； Neoepitope； T cell epitope prediction； Tumor antigen Zhang, Guanglan Chitkushev, Lou Olsen, Lars Rønn Keskin, Derin B. Brusic, Vladimir TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes |
| title | TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes |
| title_full | TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes |
| title_fullStr | TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes |
| title_full_unstemmed | TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes |
| title_short | TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes |
| title_sort | tantigen 2.0: a knowledge base of tumor t cell antigens and epitopes |
| topic | Cancer vaccine； Immunotherapy； Neoantigen； Neoepitope； T cell epitope prediction； Tumor antigen |
| url | https://eprints.nottingham.ac.uk/65316/ https://eprints.nottingham.ac.uk/65316/ https://eprints.nottingham.ac.uk/65316/ |