Design, Synthesis and Disposition Studies of New ISRIB Analogues, Targeting eIF2B, as Potential Candidates for enhancing protein synthesis rate

QR Code

Design, Synthesis and Disposition Studies of New ISRIB Analogues, Targeting eIF2B, as Potential Candidates for enhancing protein synthesis rate

Neurodegenerative diseases represent a major cause of dementia, which is predominantly a disease of the elderly, and is characterised by a decline in cognitive functions and memory. All these diseases share a similar aetiology, i.e. the production and accumulation of misfolded proteins in the brain....

Full description

Bibliographic Details
Main Author:	Abo Alard, Akeel
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2021
Subjects:	neurogeneration dementia proteins ISRIB ISR
Online Access:	https://eprints.nottingham.ac.uk/65313/

Similar Items

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B
by: Zyryanova, Alisa F., et al.
Published: (2018)

Synthesis, in vitro evaluation, and radiolabeling of fluorinated puromycin analogues: potential candidates for PET imaging of protein synthesis
by: Betts, Helen M., et al.
Published: (2016)

Aggregation Prone Region analogues: synthetic excipients for protein formulation
by: Foralosso, Ruggero
Published: (2019)

Metal-based combinations that target protein synthesis by fungi
by: Vallières, Cindy, et al.
Published: (2017)

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation
by: Soukarieh, Fadi, et al.
Published: (2016)

"Here everyone is the same" - a qualitative evaluation of participating in a Boccia (indoor bowling) group: innovative practice
by: Ovenden, Imogen, et al.
Published: (2016)

Swimming for dementia: an exploratory qualitative study
by: Hobden, Tanya, et al.
Published: (2018)

Synthesis and activity evaluation of short antifreeze peptides of type I shorthorn sculpin antifreeze protein
by: Suliman Warrad, Ahmad Omar Abdelazim
Published: (2013)

DEF6 is associated with the translational initiation regulating protein synthesis of eIF4E, 4E-T and PABP and colocalises with eIF4E and PABP in the immunological synapse
by: Alsayegh, Maha
Published: (2018)

Dyadic construction of dementia: meta-ethnography and behaviour-process synthesis
by: Bosco, Alessandro
Published: (2018)

The influence of N6-methyladenosine (m6A) RNA methylation on synaptic function and local protein synthesis
by: Martinez De La Cruz, Braulio
Published: (2020)

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
by: Crespillo-Casado, Ana, et al.
Published: (2017)

Screening, design, synthesis and bioactivity of inhibitors against Protein Arginine Deiminase type IV
by: Teo, Chian Ying
Published: (2015)

The Palliative Care Service Enhancement program: specialised palliative care services for people with behaviours and psychological symptoms of dementia in Australia
by: Atee, Mustafa, et al.
Published: (2024)

Protective Efficacy Evaluation of NPt-NPt-VP1₁₋₁₀₀Protein as a Candidate Vaccine Against Enterovirus 71 Infections in Mouse Model
by: Ch'ng, Wei Choong
Published: (2010)

Theoretical study of the electronic spectra of small molecules that incorporate analogues of the copper-cysteine bond
by: Do, Hainam, et al.
Published: (2012)

Design, Synthesis, and Development of Novel Fluorescently Labelled Allosteric Probes for the Human Beta2-Adrenoceptor
by: Tuzer, Cemre
Published: (2023)

Exploring flavour generation pathways in plant-based meat analogues
by: Plant, Alexandra
Published: (2025)

The Development of Candidate Therapeutics for Transmissible Spongiform Encephalopathies
by: Zolnierczyk, Katarzyna
Published: (2021)

Cell-free protein synthesis for on-site and on-demand biomanufacturing in extreme and low resource environments
by: Shivakumar, Tejasvi
Published: (2024)

Fidelity and coordination of mitochondrial protein synthesis in health and disease
by: Rudler, D.L., et al.
Published: (2021)

The great outdoors
by: Argyle, Elaine
Published: (2016)

Design, synthesis and activity studies of antifreeze peptide derived from type I shorthorn sculpin
by: Asmawi, Azren Aida
Published: (2015)

Characterising candidate Fusarium graminearum effectors
by: Kanja, Claire
Published: (2023)

Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men
by: Atherton, Philip J., et al.
Published: (2016)

Identifying people with dementia for epidemiological analysis in electronic primary care records in the UK
by: Kang, Sujin
Published: (2018)

Accelerated protein synthesis via one–pot ligation–deselenization chemistry
by: Mitchell, Nicholas J., et al.
Published: (2017)

Total synthesis of argyrin A and analogues thereof
by: Chen, Chou-Hsiung
Published: (2013)

The synthesis and biological evaluation of novel analogues of isocryptolepine
by: Whittell, Louise Renee'
Published: (2011)

Synthesis, Characterization And Analgesic Activity Of Mitragynine Analogues
by: Ramlee, Nurul Izzati
Published: (2015)

A synthesis of the evidence on peer-research with potentially vulnerable adults: how this relates to dementia
by: Di Lorito, Claudio, et al.
Published: (2017)

Continuing to care for people with dementia: Irish family carers' experience of their relative's transition to a nursing home
by: Argyle, Elaine, et al.
Published: (2010)

The treatment of hypertension in people with dementia
by: Welsh, Tomas J.
Published: (2016)

A shortened version of the Dementia Drivers’ Screening Assessment
by: Lincoln, Nadina, et al.
Published: (2014)

Music in dementia care: a review of interactive and receptive musical activities
by: Morris, Elizabeth
Published: (2021)

Predicting fitness to drive of people with dementia in Iraq
by: Rashid, Roshe
Published: (2020)

Effects of zerumbone on anxiety, learning and memory in scopolamine-induced animal model of dementia
by: Nasserizad, Sahba Jafarian
Published: (2019)

Mementos from Boots multisensory boxes: qualitative evaluation of an intervention for people with dementia: innovative practice
by: Griffiths, Sarah, et al.
Published: (2016)

Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer's disease: potential interactive effects of APOE genotype with dietary fats
by: D'Alonzo, Zachary, et al.
Published: (2023)

Part A: Application of fluorescent markers onto CRISPR-associated proteins/ Part B: Substitution of cysteine residues in CRISPR associated Protein Cas1
by: Parr, Lochlan
Published: (2024)