Additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering
Composites of biodegradable phosphate glass fiber and polylactic acid (PGF/PLA) show potential for bone tissue engineering scaffolds, due to their ability to release Ca, P, and Mg during degradation, thus promoting the bone repair. Nevertheless, glass degradation tends to acidify the surrounding aqu...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/64724/ |
| _version_ | 1848800157867442176 |
|---|---|
| author | He, Lizhe Liu, Xiaoling Rudd, Chris |
| author_facet | He, Lizhe Liu, Xiaoling Rudd, Chris |
| author_sort | He, Lizhe |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Composites of biodegradable phosphate glass fiber and polylactic acid (PGF/PLA) show potential for bone tissue engineering scaffolds, due to their ability to release Ca, P, and Mg during degradation, thus promoting the bone repair. Nevertheless, glass degradation tends to acidify the surrounding aqueous environment, which may adversely affect the viability and bone-forming activities of osteoblasts. In this work, MgO was investigated as a neutralizing agent. Porous network-phase gyroid scaffolds were additive-manufactured using four different materials: PLA, MgO/PLA, PGF/PLA, and (MgO + PGF)/PLA. The addition of PGF enhanced compressive properties of scaffolds, and the resultant scaffolds were comparably strong and stiff with human trabecular bone. While the degradation of PGF/PLA composite induced considerable acidity in degradation media and intensified the degradation of PGF in return, the degradation media of (MgO + PGF)/PLA maintained a neutral pH close to a physiological environment. The experiment results indicated the possible mechanism of MgO as the neutralizing agent: the local acidity was buffered as the MgO reacted with the acidic degradation products thereby inhibiting the degradation of PGF from being intensified in an acidic environment. The (MgO + PGF)/PLA composite scaffold appears to be a candidate for bone tissue engineering. |
| first_indexed | 2025-11-14T20:47:06Z |
| format | Article |
| id | nottingham-64724 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:47:06Z |
| publishDate | 2021 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-647242021-03-10T06:19:49Z https://eprints.nottingham.ac.uk/64724/ Additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering He, Lizhe Liu, Xiaoling Rudd, Chris Composites of biodegradable phosphate glass fiber and polylactic acid (PGF/PLA) show potential for bone tissue engineering scaffolds, due to their ability to release Ca, P, and Mg during degradation, thus promoting the bone repair. Nevertheless, glass degradation tends to acidify the surrounding aqueous environment, which may adversely affect the viability and bone-forming activities of osteoblasts. In this work, MgO was investigated as a neutralizing agent. Porous network-phase gyroid scaffolds were additive-manufactured using four different materials: PLA, MgO/PLA, PGF/PLA, and (MgO + PGF)/PLA. The addition of PGF enhanced compressive properties of scaffolds, and the resultant scaffolds were comparably strong and stiff with human trabecular bone. While the degradation of PGF/PLA composite induced considerable acidity in degradation media and intensified the degradation of PGF in return, the degradation media of (MgO + PGF)/PLA maintained a neutral pH close to a physiological environment. The experiment results indicated the possible mechanism of MgO as the neutralizing agent: the local acidity was buffered as the MgO reacted with the acidic degradation products thereby inhibiting the degradation of PGF from being intensified in an acidic environment. The (MgO + PGF)/PLA composite scaffold appears to be a candidate for bone tissue engineering. MDPI AG 2021-01-15 Article PeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/64724/1/Additive-manufactured%20gyroid%20scaffolds%20of%20magnesium%20oxide%2C%20phosphate%20glass%20fiber%20and%20polylactic%20acid%20composite%20for%20bone%20tissue%20engineering.pdf He, Lizhe, Liu, Xiaoling and Rudd, Chris (2021) Additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering. Polymers, 13 (2). p. 270. ISSN 2073-4360 additive manufacturing; phosphate glass fiber; polylactic acid; gyroid; bone tissue engineering scaffold http://dx.doi.org/10.3390/polym13020270 doi:10.3390/polym13020270 doi:10.3390/polym13020270 |
| spellingShingle | additive manufacturing; phosphate glass fiber; polylactic acid; gyroid; bone tissue engineering scaffold He, Lizhe Liu, Xiaoling Rudd, Chris Additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering |
| title | Additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering |
| title_full | Additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering |
| title_fullStr | Additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering |
| title_full_unstemmed | Additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering |
| title_short | Additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering |
| title_sort | additive-manufactured gyroid scaffolds of magnesium oxide, phosphate glass fiber and polylactic acid composite for bone tissue engineering |
| topic | additive manufacturing; phosphate glass fiber; polylactic acid; gyroid; bone tissue engineering scaffold |
| url | https://eprints.nottingham.ac.uk/64724/ https://eprints.nottingham.ac.uk/64724/ https://eprints.nottingham.ac.uk/64724/ |