Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device
Efficient and effective separation of circulating tumor cells from biological samples to promote early diagnosis of cancer is important but challenging, especially for non-small cell lung cancer (NSCLC). In this article, a Y-Y shaped microfluidic device was designed to isolate NSCLC cells with a die...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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2020
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| Online Access: | https://eprints.nottingham.ac.uk/63062/ |
| _version_ | 1848799991792926720 |
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| author | Zhang, Xiangzhi Xu, Xiawei Ren, Yong Yan, Yuying Wu, Aiguo |
| author_facet | Zhang, Xiangzhi Xu, Xiawei Ren, Yong Yan, Yuying Wu, Aiguo |
| author_sort | Zhang, Xiangzhi |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Efficient and effective separation of circulating tumor cells from biological samples to promote early diagnosis of cancer is important but challenging, especially for non-small cell lung cancer (NSCLC). In this article, a Y-Y shaped microfluidic device was designed to isolate NSCLC cells with a dielectrophoresis approach. Numerical simulations were conducted that the trajectories of cells were traced by solving the electric potential distribution and the flow field in a microchannel. The effects of inlet flow rate ratio of blood sample and buffer on separation performance were studied and optimized by the numerical investigation. Under optimal operating conditions, the separation efficiency can reach around 99%, which is achieved with 100 kHz AC, electrodes potential ranging from 1.6 V to 2.2 V, and flow rate ratio from 1.9 to 2.5. This study presents a potentially efficient, facile and low-cost route for circulating tumor cell separation. |
| first_indexed | 2025-11-14T20:44:28Z |
| format | Article |
| id | nottingham-63062 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:44:28Z |
| publishDate | 2020 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-630622020-09-17T06:16:16Z https://eprints.nottingham.ac.uk/63062/ Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device Zhang, Xiangzhi Xu, Xiawei Ren, Yong Yan, Yuying Wu, Aiguo Efficient and effective separation of circulating tumor cells from biological samples to promote early diagnosis of cancer is important but challenging, especially for non-small cell lung cancer (NSCLC). In this article, a Y-Y shaped microfluidic device was designed to isolate NSCLC cells with a dielectrophoresis approach. Numerical simulations were conducted that the trajectories of cells were traced by solving the electric potential distribution and the flow field in a microchannel. The effects of inlet flow rate ratio of blood sample and buffer on separation performance were studied and optimized by the numerical investigation. Under optimal operating conditions, the separation efficiency can reach around 99%, which is achieved with 100 kHz AC, electrodes potential ranging from 1.6 V to 2.2 V, and flow rate ratio from 1.9 to 2.5. This study presents a potentially efficient, facile and low-cost route for circulating tumor cell separation. 2020-07-09 Article PeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/63062/1/yan.pdf Zhang, Xiangzhi, Xu, Xiawei, Ren, Yong, Yan, Yuying and Wu, Aiguo (2020) Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device. Separation and Purification Technology, 255 . p. 117343. ISSN 13835866 Microfluidics; Circulating tumor cells; Separation; Dielectrophoresis http://dx.doi.org/10.1016/j.seppur.2020.117343 doi:10.1016/j.seppur.2020.117343 doi:10.1016/j.seppur.2020.117343 |
| spellingShingle | Microfluidics; Circulating tumor cells; Separation; Dielectrophoresis Zhang, Xiangzhi Xu, Xiawei Ren, Yong Yan, Yuying Wu, Aiguo Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device |
| title | Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device |
| title_full | Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device |
| title_fullStr | Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device |
| title_full_unstemmed | Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device |
| title_short | Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device |
| title_sort | numerical simulation of circulating tumor cell separation in a dielectrophoresis based y-y shaped microfluidic device |
| topic | Microfluidics; Circulating tumor cells; Separation; Dielectrophoresis |
| url | https://eprints.nottingham.ac.uk/63062/ https://eprints.nottingham.ac.uk/63062/ https://eprints.nottingham.ac.uk/63062/ |