Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study
Background Cross‐sectional studies show that transgender people are more likely than cisgender people to experience depression and anxiety before Gender Affirming Hormone Treatment (GAHT). However, the effect of GAHT on mental health in transgender people, and the role of other factors that may h...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://eprints.nottingham.ac.uk/61355/ |
| _version_ | 1848801189637914624 |
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| author | Aldridge, Zoë Patel, Shireen Guo, Boliang Nixon, Elena Pierre Bouman, Walter Witcomb, Gemma L. Arcelus, Jon |
| author_facet | Aldridge, Zoë Patel, Shireen Guo, Boliang Nixon, Elena Pierre Bouman, Walter Witcomb, Gemma L. Arcelus, Jon |
| author_sort | Aldridge, Zoë |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background
Cross‐sectional studies show that transgender people are more likely than cisgender people to experience depression and anxiety before Gender Affirming Hormone Treatment (GAHT). However, the effect of GAHT on mental health in transgender people, and the role of other factors that may have a predictive effect, is poorly explored.
Objectives
Using a longitudinal methodology, this study investigated the effect of 18 months GAHT on depression and anxiety symptomatology and the predictors on mental health outcomes in a large population of transgender people.
Materials and Methods
Participants (n=178) completed a socio‐demographic questionnaire, the Hospital Anxiety and Depression Scale (HADS), the Multidimensional Scale of Perceived Social Support (MSPSS) and the Autism Spectrum Quotient Short Version (AQ‐short) at pre‐assessment (T0) and at 18 months after initiation of GAHT (T1).
Results
From T0 to T1, symptomatology was significantly decreased for depression (P <0.001) and non‐significantly reduced for anxiety (P=0.37). Scores on the MSPSS predicted reduction in depression, while scores on the AQ‐short predicted reduction in anxiety.
Discussion
GAHT reduces symptoms of depression which are predicted by having higher levels of social support. Although anxiety symptoms also reduce the changes are not significant and high levels of anxiety still remain post GAHT.
Conclusions
These results highlight the important mental health benefits of GAHT. Support services (professional, third sector or peer‐support) aiming at increasing social support for transgender individuals should be made available. |
| first_indexed | 2025-11-14T20:42:28Z |
| format | Article |
| id | nottingham-61355 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:03:30Z |
| publishDate | 2020 |
| recordtype | eprints |
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| spelling | nottingham-613552025-09-12T09:03:46Z https://eprints.nottingham.ac.uk/61355/ Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study Aldridge, Zoë Patel, Shireen Guo, Boliang Nixon, Elena Pierre Bouman, Walter Witcomb, Gemma L. Arcelus, Jon Background Cross‐sectional studies show that transgender people are more likely than cisgender people to experience depression and anxiety before Gender Affirming Hormone Treatment (GAHT). However, the effect of GAHT on mental health in transgender people, and the role of other factors that may have a predictive effect, is poorly explored. Objectives Using a longitudinal methodology, this study investigated the effect of 18 months GAHT on depression and anxiety symptomatology and the predictors on mental health outcomes in a large population of transgender people. Materials and Methods Participants (n=178) completed a socio‐demographic questionnaire, the Hospital Anxiety and Depression Scale (HADS), the Multidimensional Scale of Perceived Social Support (MSPSS) and the Autism Spectrum Quotient Short Version (AQ‐short) at pre‐assessment (T0) and at 18 months after initiation of GAHT (T1). Results From T0 to T1, symptomatology was significantly decreased for depression (P <0.001) and non‐significantly reduced for anxiety (P=0.37). Scores on the MSPSS predicted reduction in depression, while scores on the AQ‐short predicted reduction in anxiety. Discussion GAHT reduces symptoms of depression which are predicted by having higher levels of social support. Although anxiety symptoms also reduce the changes are not significant and high levels of anxiety still remain post GAHT. Conclusions These results highlight the important mental health benefits of GAHT. Support services (professional, third sector or peer‐support) aiming at increasing social support for transgender individuals should be made available. 2020-08-10 Article PeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/61355/1/AAM_1.pdf Aldridge, Zoë, Patel, Shireen, Guo, Boliang, Nixon, Elena, Pierre Bouman, Walter, Witcomb, Gemma L. and Arcelus, Jon (2020) Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study. Andrology . ISSN 2047-2919 Hormone therapy Transgender Longitudinal Mental health Social support Autism http://dx.doi.org/10.1111/andr.12884 10.1111/andr.12884 10.1111/andr.12884 10.1111/andr.12884 |
| spellingShingle | Hormone therapy Transgender Longitudinal Mental health Social support Autism Aldridge, Zoë Patel, Shireen Guo, Boliang Nixon, Elena Pierre Bouman, Walter Witcomb, Gemma L. Arcelus, Jon Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study |
| title | Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study |
| title_full | Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study |
| title_fullStr | Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study |
| title_full_unstemmed | Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study |
| title_short | Long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: A prospective cohort study |
| title_sort | long term effect of gender affirming hormone treatment on depression and anxiety symptoms in transgender people: a prospective cohort study |
| topic | Hormone therapy Transgender Longitudinal Mental health Social support Autism |
| url | https://eprints.nottingham.ac.uk/61355/ https://eprints.nottingham.ac.uk/61355/ https://eprints.nottingham.ac.uk/61355/ |