Dynamics of VEGF-A binding at VEGFR2 and NRP1

QR Code

Dynamics of VEGF-A binding at VEGFR2 and NRP1

Vascular Endothelial Growth Factor A (VEGF-A) is a key mediator of angiogenesis, a process dysregulated in tumour development. Alternative splicing of the Vegfa gene leads to distinct endogenous VEGF-A isoforms with differential signalling and expression. These include pro-angiogenic VEGF165a, ‘anti...

Full description

Bibliographic Details
Main Author:	Peach, Chloe J
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	Pharmacology Angiogenesis Growth factor
Online Access:	https://eprints.nottingham.ac.uk/60840/

Similar Items

Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
by: Peach, Chloe, et al.
Published: (2018)

Real-time ligand binding of fluorescent VEGF-A isoforms that discriminate between VEGFR2 and NRP1 in living cells
by: Peach, Chloe J., et al.
Published: (2018)

Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt the vascular maturation in infantile haemangioma
by: Ye, Xi, et al.
Published: (2016)

The effects of EPHA2 inhibition on VEGF, VEGFR-1 and VEGFR-2 in human malignant glioma cells
by: Baharuddin, Wan Noor Ainun
Published: (2018)

Differential regulation of blood flow induced neovascularisation and mural cell recruitment by VEGF and angiopoietin signaling
by: Stone, Oliver A., et al.
Published: (2017)

Effects of small molecule inhibitors targeting PI3K, EGFR, IGF-1R, MTOR, SMAD3 and MEK in tube formation and 3-D spheroid assay
by: Ng, Chin Tat
Published: (2014)

Real-time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
by: Kilpatrick, Laura E., et al.
Published: (2017)

Exploring the potential role of endothelial ZEB1 in developmental and pathological angiogenesis
by: Green, Kathryn
Published: (2025)

VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney
by: Stevens, Megan, et al.
Published: (2017)

Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response
by: Smith, Stuart J., et al.
Published: (2015)

Development of quinone-rich fraction of Ardisia crispa (Thunb.) A.DC roots mitigates rheumatoid arthritis by suppressing angiogenesis, in vitro and in vivo
by: Blin, Joan
Published: (2021)

Effects of receptor tyrosine kinase inhibitors on VEGF165a- and VEGF165b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2
by: Carter, Joanne J., et al.
Published: (2015)

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)
by: Barratt, Shaney L., et al.
Published: (2018)

Pattern Formation by Lateral Inhibition in Physiological and Tumour Angiogenesis
by: Smith, Holly
Published: (2020)

Pigment epithelium-derived factor as a natural matrix metalloproteinase inhibitor: a comparison with classical matrix metalloproteinase inhibitors used for cancer treatment
by: Alcantara, M., et al.
Published: (2014)

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer
by: Shrimali, D., et al.
Published: (2013)

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma
by: Smith, Stuart J., et al.
Published: (2012)

Development of a growth factor delivery system
by: Kirby, Giles T.S.
Published: (2014)

Step up in the Neonatal Resuscitation Program (NRP). Updates from NRP 7th edition
by: Mohamed, Mossad Abdelhak Shaban, et al.
Published: (2019)

The role and regulation of angiogenesis during key stages of ovarian follicle development
by: Nwachukwu, Chinwe Uchechi
Published: (2019)

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development
by: Metzler, Veronika M., et al.
Published: (2017)

Expression of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in thyroid nodular hyperplasia and papillary thyroid carcinoma (PTC)
by: Razy, Nur Hidayati Mohamad Pakarul
Published: (2017)

Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies
by: Nemazannikova, N., et al.
Published: (2014)

Cardiovascular safety liabilities of VEGFR-2 inhibitors
by: Pannucci, Patrizia
Published: (2024)

Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production
by: Glister, Claire, et al.
Published: (2013)

Mechanisms regulating angiogenesis underlie seasonal control of pituitary function
by: Castle-Miller, Jennifer, et al.
Published: (2017)

Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer
by: Ko, S., et al.
Published: (2014)

Synthesis, characterisation and biological activities of mixed-ligand copper(II) complexes containing saccharin as one of the ligands
by: Begum, Thahira
Published: (2005)

The potential role of free chitosan in bone trauma and bone cancer management
by: Tan, M., et al.
Published: (2014)

Gene therapy using plasmid DNA encoding vascular endothelial growth factor 164 and fibroblast growth factor 2 genes for the treatment of horse tendinitis and desmitis: case reports
by: Kovac, Milomir, et al.
Published: (2017)

Luteal angiogenesis and its control
by: Woad, Kathryn J., et al.
Published: (2016)

Mathematical analysis of a model for the growth of the bovine corpus luteum.
by: Prokopiou, Sotiris A., et al.
Published: (2014)

Use other metrics to determine NRP timeline, urges expert
by: New Straits Times
Published: (2021)

Identification of genes and pathways regulated by the PRH/HHEX transcription factor in endothelial and lymphatic cells
by: Dahhan, Rania
Published: (2024)

Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep
by: Hyatt, M.A., et al.
Published: (2007)

Healing properties of epidermal growth factor and tocotrienol-rich fraction formulation in deep partial-thickness burn wound model
by: Guo, Hui-Fang
Published: (2017)

Supplementation of postbiotic RG14 in post-weaning dorper lambs to enhance growth performance, gut health and immunity
by: Wan Ibrahim, Wan Ahmad Izuddin
Published: (2018)

Control of collateral formation as a therapeutic for cardiovascular disease
by: Amartey, Jason
Published: (2024)

Antinociceptive and anti inflammatory activities of 3-(2,5 dimethoxyphenyl)-1-(5 methylfuran-2-YL) prop-2-en-1 in mice
by: Abu Bakar, Noor Azlina
Published: (2016)

Biological significance of human epidermal growth factor receptor 2 (HER2) in breast cancer: effect of oestrogen receptor
by: Ahmad, Dena Akram Jerjees
Published: (2016)