Investigating the interplay between Wilms’ Tumour Protein 1 and oxidised forms of 5-Methylcytosine in brain tumours

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Investigating the interplay between Wilms’ Tumour Protein 1 and oxidised forms of 5-Methylcytosine in brain tumours

5-methylcytosine (5mC) is an epigenetic modification usually associated with transcriptional repression. The Ten–Eleven Translocation proteins (Tet1/2/3) can oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in vertebrate DNA. These modifications hav...

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Bibliographic Details
Main Author:	Ramsawhook, Ashley
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	Epigenetics; Brain tumours; Stem cells; DNA demethylation
Online Access:	https://eprints.nottingham.ac.uk/60006/

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