Theoretical and experimental evaluation of the effects of hydrostatic pressure on hepatocyte metabolic capacity

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Theoretical and experimental evaluation of the effects of hydrostatic pressure on hepatocyte metabolic capacity

Drug discovery is a lengthy and expensive process costing ~$2.6 billion per new chemical entity. To reduce this cost, potential new drugs undergo extensive testing through a series of drug metabolism and pharmacokinetic (DMPK) assays designed to ensure that only the most suitable candidates progress...

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Bibliographic Details
Main Author:	Burton, Lewis
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2020
Subjects:	Hepatocytes; Static pressure; Liver lobule; Hydrostatic pressure; Metabolic competency; CYP450
Online Access:	https://eprints.nottingham.ac.uk/59708/

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