Modelling Immunological Memory
Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Book Section |
| Published: |
Springer
2006
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| Online Access: | https://eprints.nottingham.ac.uk/585/ |
| _version_ | 1848790437058314240 |
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| author | Garrett, Simon Robbins, Martin Walker, Joanne Wilson, William Aickelin, Uwe |
| author2 | Flower, D |
| author_facet | Flower, D Garrett, Simon Robbins, Martin Walker, Joanne Wilson, William Aickelin, Uwe |
| author_sort | Garrett, Simon |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then use the same system to evaluate the predicted effects of a theory of immunological memory. The resulting model has not been explored before in artificial immune systems research, and we compare the simulated in silico output with in vivo measurements. Although the theory appears valid, we suggest that there are a common set of reasons why immunological memory models are a useful support tool; not conclusive in themselves. |
| first_indexed | 2025-11-14T18:12:36Z |
| format | Book Section |
| id | nottingham-585 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:12:36Z |
| publishDate | 2006 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-5852020-05-04T20:29:51Z https://eprints.nottingham.ac.uk/585/ Modelling Immunological Memory Garrett, Simon Robbins, Martin Walker, Joanne Wilson, William Aickelin, Uwe Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then use the same system to evaluate the predicted effects of a theory of immunological memory. The resulting model has not been explored before in artificial immune systems research, and we compare the simulated in silico output with in vivo measurements. Although the theory appears valid, we suggest that there are a common set of reasons why immunological memory models are a useful support tool; not conclusive in themselves. Springer Flower, D Timmis, J 2006 Book Section PeerReviewed Garrett, Simon, Robbins, Martin, Walker, Joanne, Wilson, William and Aickelin, Uwe (2006) Modelling Immunological Memory. In: Silico Immunology. Springer, pp. 83-108. |
| spellingShingle | Garrett, Simon Robbins, Martin Walker, Joanne Wilson, William Aickelin, Uwe Modelling Immunological Memory |
| title | Modelling Immunological Memory |
| title_full | Modelling Immunological Memory |
| title_fullStr | Modelling Immunological Memory |
| title_full_unstemmed | Modelling Immunological Memory |
| title_short | Modelling Immunological Memory |
| title_sort | modelling immunological memory |
| url | https://eprints.nottingham.ac.uk/585/ |