Understanding certain Clostridium difficile virulence and antibiotic resistance factors and how these relate to patient clinical outcome

QR Code

Understanding certain Clostridium difficile virulence and antibiotic resistance factors and how these relate to patient clinical outcome

Clostridium difficile is known for causing the nosocomial diarrhoeal disease, C. difficile infection (CDI). The aim of this study was to investigate the molecular and phenotypic basis of certain C. difficile virulence factors, such as C. difficile transferase (CDT) and sporulation, as well as rifaxi...

Full description

Bibliographic Details
Main Author:	Kinsmore, Natasha Louise
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	C. difficile virulence factors; C. difficile transferase; Sporulation; Rifaximin antibiotic resistance
Online Access:	https://eprints.nottingham.ac.uk/57076/

Similar Items

Spore germination and recurrence of clostridioides difficile infection
by: Finch, Lorna
Published: (2020)

Analysis of the spore germination mechanisms of Clostridium difficile
by: Burns, David Alexander
Published: (2011)

Development of Clostridium difficile R20291ΔPaLoc model strains and in vitro methodologies reveals CdtR is required for the production of CDT to cytotoxic levels
by: Bilverstone, T.W., et al.
Published: (2017)

The antimicrobial and bile acid mediated control of Clostridium difficile infection
by: Dempster, Andrew William
Published: (2018)

Developing a protein subunit oral vaccine against Clostridioides difficile
by: Wood, Liam
Published: (2023)

Identification and characterisation of potential bacteriocins with biological activity against Clostridium difficile from environmental samples
by: Kim, Sungchan
Published: (2018)

Isolation and characterisation of four novel bacteriophages infecting clinically relevant PCR ribotypes of Clostridium difficile
by: Whittle, Michaella
Published: (2018)

Investigation of the effect of insertional mutation in agr and sigB loci in Clostridium difficile R20291
by: Montfort-Gardeazabal, Jorge M.
Published: (2017)

Exposing hidden putative lipoproteins in Clostridium difficile
by: Griffin, R., et al.
Published: (2017)

Identification and characterisation of tail components modulating host range of Clostridium difficile phages
by: Steczynska, Joanna
Published: (2023)

Both, toxin A and toxin B, are important in Clostridium difficile infection
by: Kuehne, Sarah A., et al.
Published: (2011)

Amino acids utilisation by Clostridium difficile strains
by: Ogbu, H.I.
Published: (2016)

Towards development of a liposome-based vaccine to combat Clostridium difficile infection
by: Palazi, Panayiota
Published: (2021)

Profiling humoral immune responses to Clostridium difficile-specific antigens by protein microarray analysis
by: Negm, Ola H., et al.
Published: (2015)

Transposon mutagenesis in RT 078 Clostridioides difficile
by: te Vrugt, Marcel
Published: (2023)

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration
by: Negm, Ola H., et al.
Published: (2017)

Importance of Toxin A, Toxin B, and CDT in virulence of an epidemic Clostridium difficile strain
by: Kuehne, Sarah A., et al.
Published: (2013)

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection
by: Monaghan, Tanya M., et al.
Published: (2017)

Development of an oral vaccine against Clostridioides difficile
by: Karyal, Cansu
Published: (2021)

What's a SNP between friends: the influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives
by: Collery, Mark M., et al.
Published: (2016)

Investigating the bile acid mediated control of Clostridioides difficile infection
by: von Emloh, Louise
Published: (2024)

Mucosal cell responses to Clostridium difficile toxins
by: Mullan, Nivette K.
Published: (2011)

CdtR-mediated regulation of toxin production in Clostridium difficile
by: Bilverstone, Terry W.
Published: (2019)

A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection
by: Negm, Ola H., et al.
Published: (2018)

Identification and characterisation of novel bacteriocins active against Clostridioides difficile
by: Chapman, Sarah May Olivia
Published: (2020)

A recombinant non-toxigenic Clostridioides difficile spore vaccine directed against toxigenic C. difficile
by: Aston, Carl
Published: (2022)

Tackling antimicrobial resistance through two novel methods: repurposing vanoxerine as a novel anti-tubercular drug; and silencing virulence in Pseudomonas aeruginosa through inhibition of PqsR
by: Grossman, Scott
Published: (2018)

Obtaining a lytic bacteriophage suitable for use in phage therapy against Clostridioides difficile infection
by: Kerr, Sarah
Published: (2023)

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile
by: van Eijk, Erika, et al.
Published: (2016)

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile
by: van Eijk, Erika, et al.
Published: (2016)

A genetic assay for gene essentiality in Clostridium
by: Walker, David J.F., et al.
Published: (2016)

In silico identification of Meyerozyma guilliermondii strain so potential virulence factors and pathogenicity verification of generated mutants in zebrafish model
by: Lim, Si Jie
Published: (2024)

Domain swapping to generate new antibiotic proteins
by: Kapp, James
Published: (2024)

Illness Severity in Community-Onset Invasive Staphylococcus aureus Infection and the Presence of Virulence Genes
by: Wehrhahn, M., et al.
Published: (2012)

Microstructure and properties of C/C–ZrC composites prepared by hydrothermal deposition combined with carbothermal reduction
by: Li, Cuiyan, et al.
Published: (2018)

Characterisation of a putative quorum sensing system in Colstridium difficile
by: Patel, Manisha R.
Published: (2011)

Molecular characterization and antibiotic susceptibility of methicillin resistant staphylococcus aureus isolated from chickens and cattle
by: Magashi, Abbulkadir Magaji
Published: (2012)

Investigating lung function gene GSTCD using gene targeting in human and mouse systems
by: Probert, Kelly
Published: (2016)

NirA is an alternative nitrite reductase from Pseudomonas aeruginosa with potential as an anti-virulence target
by: Fenn, Samuel Jacob
Published: (2022)

Relationship between virulence factor and toxin antitoxin system in enterococcus
by: Soheili, Sara
Published: (2014)