Cigarette smoke extract reduces the anti-inflammatory effect of fluticasone in human airway smooth muscle cells

QR Code

Cigarette smoke extract reduces the anti-inflammatory effect of fluticasone in human airway smooth muscle cells

Background: Airway inflammation is a hallmark of asthma disease, and cytokines play a major role in the inflammation process. Human airway smooth muscle cells (HASMCs) are considered as an important source of inflammatory cytokines and chemokines in Asthma. Inhaled corticosteroids (ICS) are used w...

Full description

Bibliographic Details
Main Author:	Alghamdi, Abdulrhman
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	Airway inflammation; Inflammatory cytokines and chemokines; Inhaled corticosteroids; Steroid sensitivity; Fluticasone
Online Access:	https://eprints.nottingham.ac.uk/56758/

Similar Items

Effect of cigarette smoke extract and IL-17A on T2 and non-T2 inflammatory responses in human airway smooth muscle cells
by: Alghamdi, Abdulrhman
Published: (2022)

Effect of cigarette smoke extract and electronic cigarette vapour extract on the production of cytokines and chemokines in human airway smooth muscle cells
by: Alshehri, Wael
Published: (2019)

Cigarette smoke extract induces inflammatory cytokine and chemokine production in human bronchial epithelial cells
by: Alshehri, Mohammed
Published: (2018)

Effect of cigarette smoke extract on inflammatory cytokine production and corticosteroid insensitivity in human airway smooth muscle cells
by: Alahmari, Mushabbab
Published: (2022)

Investigating the symptoms of airways disease
by: Martin, Matthew J.
Published: (2017)

Novel inflammatory cell infiltration scoring system to investigate healthy and footrot affected ovine interdigital skin
by: Agbaje, Michael, et al.
Published: (2018)

An evaluation of a price transparency intervention for two commonly prescribed medications on total institutional expenditure: a prospective study
by: Langley, Tessa, et al.
Published: (2018)

Utility of the precision cut lung slice model to investigate airway smooth muscle contraction
by: Fox, Jane
Published: (2011)

The effect of the timing of exposure to Campylobacter jejuni on the gut microbiome and inflammatory responses of broiler chickens
by: Connerton, Phillippa L., et al.
Published: (2018)

Electronic monitoring devices in asthma: translating from study use into clinical practice
by: Adejumo, Ireti D.
Published: (2021)

Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs
by: Tanino, Y., et al.
Published: (2010)

Assessment of the biological consequences of controlling indoor solid fuel smoke emissions in Nepal
by: K.C., Binaya
Published: (2020)

A review of standard pharmacological therapy for adult asthma - Steps 1 to 5
by: Patel, Mitesh Dilipkumar Kantilal, et al.
Published: (2015)

Investigating the factors affecting adherence to inhaled corticosteroids in patients with asthma using primary care data in the UK
by: Taylor, Amelia C.
Published: (2017)

Orbital inflammatory complications of Crohn’s disease: a rare case series
by: Monaghan, Tanya M., et al.
Published: (2018)

Potential antioxidant and anti-inflammatory effects of Erythroxylum cuneatum (Miq.) Kurz leaf extract against oxidised low-density lipoprotein in human aortic endothelial cell
by: Shanmugam, Nitya
Published: (2020)

Elucidation of the anti-inflammatory compound present in Jatropha curcas Linn Root and its mode of action
by: Othman, Ahmad Razi
Published: (2016)

Identifying stem cells role in ulcerative colitis by bioinformatic analyses
by: Ordonez Moran, P.
Published: (2024)

Biomarkers of airway inflammation: the use of exhaled nitric oxide (FeNO) in the management of adult asthma in UK primary care
by: Wilson, Emma Elizabeth
Published: (2013)

MMP-1 activation contributes to airway smooth muscle growth and asthma severity
by: Naveed, Shams-un-nisa, et al.
Published: (2017)

A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation
by: Williams, Neil C., et al.
Published: (2016)

Inflammatory bowel disease: clinical aspects and treatments
by: Fakhoury, M., et al.
Published: (2014)

Better Targeting of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease
by: Sonnex, Kimberley
Published: (2023)

Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma
by: Donovan, G.M., et al.
Published: (2020)

The role of serum inflammatory modulators and the gut microbiome in musculoskeletal trauma
by: Zheng, Amy Sulan
Published: (2025)

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial
by: Hanratty, Catherine E., et al.
Published: (2018)

The effects of azithromycin in treatment-resistant cough: a randomized, double-blind, placebo-controlled trial
by: Hodgson, David, et al.
Published: (2016)

An in vitro and in silico study of altered airway smooth muscle structure and function in a remodelled asthmatic airway
by: Brown, Sarah
Published: (2023)

In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss
by: Chernyavsky, Igor L., et al.
Published: (2018)

Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipients
by: Ling, K.M., et al.
Published: (2019)

Modelling cell–matrix interactions in airway smooth muscle cells
by: Irons, Linda
Published: (2019)

FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations
by: Skeggs, Andrew, et al.
Published: (2016)

The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite
by: Shang, V.C.M., et al.
Published: (2016)

The attitudes of owners and veterinary professionals in the United Kingdom to the risk of adverse events associated with using non- steroidal anti-inflammatory drugs (NSAIDs) to treat dogs with osteoarthritis
by: Belshaw, Zoe, et al.
Published: (2016)

Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity
by: Singh, Shailendra R., et al.
Published: (2014)

Aberrant DNA methylation and its regulation of gene expression in airway smooth muscle cells of individuals with asthma
by: Clifford, Rachel Louise
Published: (2023)

3, 19-diacetyl-14-deoxy-11,12-didehydroandrographolide (srs27) antagonises inflammatory response and oxidative stress in in vitro and in vivo asthma models
by: Lim, Chee Woei
Published: (2014)

The role of histone arginine methylation in cytokine/chemokine gene expression in airway smooth muscle cells in asthma
by: Kaczmarek, Klaudia
Published: (2019)

Phytochemicals and Anti-Inflammatory Activity of Melicope Ptelefolia Champ Ex Benth
by: Suryati
Published: (2005)

Effect of corticosteroid therapy on influenza-related mortality: a systematic review and meta-analysis
by: Rodrigo, Chamira, et al.
Published: (2015)