Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica
Heliaquanoid A (1), the first exo-2,4-linked Diels−Alder adduct between a pseudoguaianolide dienophile and a guaianolide diene, and heliaquanoids B−E (2−5), four new 2,4-linked Diels−Alder adducts between a xanthanolide dienophile and a guaianolide diene, were isolated from stems and leaves of Inula...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2019
|
| Online Access: | https://eprints.nottingham.ac.uk/56622/ |
| _version_ | 1848799355761328128 |
|---|---|
| author | Zheng, Zai-Qin Wei, Wen-Jun Zhang, Junmin Li, Hang-Ying Xu, Kai Xu, Jiayuan Tang, Bencan Li, Ya Gao, Kun |
| author_facet | Zheng, Zai-Qin Wei, Wen-Jun Zhang, Junmin Li, Hang-Ying Xu, Kai Xu, Jiayuan Tang, Bencan Li, Ya Gao, Kun |
| author_sort | Zheng, Zai-Qin |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Heliaquanoid A (1), the first exo-2,4-linked Diels−Alder adduct between a pseudoguaianolide dienophile and a guaianolide diene, and heliaquanoids B−E (2−5), four new 2,4-linked Diels−Alder adducts between a xanthanolide dienophile and a guaianolide diene, were isolated from stems and leaves of Inula helianthus-aquatica. Their structures were determined by the NMR spectroscopy, modified Mosher′s method, electronic circular dichroism, and X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 7.5 and 4.9 μM, respectively. |
| first_indexed | 2025-11-14T20:34:21Z |
| format | Article |
| id | nottingham-56622 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:34:21Z |
| publishDate | 2019 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-566222020-03-18T04:30:15Z https://eprints.nottingham.ac.uk/56622/ Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica Zheng, Zai-Qin Wei, Wen-Jun Zhang, Junmin Li, Hang-Ying Xu, Kai Xu, Jiayuan Tang, Bencan Li, Ya Gao, Kun Heliaquanoid A (1), the first exo-2,4-linked Diels−Alder adduct between a pseudoguaianolide dienophile and a guaianolide diene, and heliaquanoids B−E (2−5), four new 2,4-linked Diels−Alder adducts between a xanthanolide dienophile and a guaianolide diene, were isolated from stems and leaves of Inula helianthus-aquatica. Their structures were determined by the NMR spectroscopy, modified Mosher′s method, electronic circular dichroism, and X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 7.5 and 4.9 μM, respectively. American Chemical Society 2019-04-05 Article PeerReviewed application/pdf en https://eprints.nottingham.ac.uk/56622/1/jo-2018-03284g.R2.pdf Zheng, Zai-Qin, Wei, Wen-Jun, Zhang, Junmin, Li, Hang-Ying, Xu, Kai, Xu, Jiayuan, Tang, Bencan, Li, Ya and Gao, Kun (2019) Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica. Journal of Organic Chemistry, 84 (7). pp. 4473-4477. ISSN 0022-3263 http://dx.doi.org/10.1021/acs.joc.8b03284 doi:10.1021/acs.joc.8b03284 doi:10.1021/acs.joc.8b03284 |
| spellingShingle | Zheng, Zai-Qin Wei, Wen-Jun Zhang, Junmin Li, Hang-Ying Xu, Kai Xu, Jiayuan Tang, Bencan Li, Ya Gao, Kun Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica |
| title | Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica |
| title_full | Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica |
| title_fullStr | Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica |
| title_full_unstemmed | Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica |
| title_short | Heliaquanoids A–E, five sesquiterpenoid dimers from Inula helianthus-aquatica |
| title_sort | heliaquanoids a–e, five sesquiterpenoid dimers from inula helianthus-aquatica |
| url | https://eprints.nottingham.ac.uk/56622/ https://eprints.nottingham.ac.uk/56622/ https://eprints.nottingham.ac.uk/56622/ |