Biological Evaluation of Synergistic Drug Combinations, Design and Synthesis of Potent and Selective PI3K Inhibitors and the Design of Bifunctional Ligands Incorporating Pictilisib & Ceritinib for the Treatment of EML4-ALK Positive Lung Cancer

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Biological Evaluation of Synergistic Drug Combinations, Design and Synthesis of Potent and Selective PI3K Inhibitors and the Design of Bifunctional Ligands Incorporating Pictilisib & Ceritinib for the Treatment of EML4-ALK Positive Lung Cancer

Lung cancer remains the leading cause of cancer death in the United Kingdom. Non-small cell lung cancer makes up the majority of all lung cancers, approximately 80-85%. Of these non-small cell lung cancers, 3-7% possess chromosomal rearrangements of anaplastic lymphoma kinase (ALK). These lead to co...

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Bibliographic Details
Main Author:	Garces, Aimie E.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	Lung cancer Pi3K prodrugs combination therapy
Online Access:	https://eprints.nottingham.ac.uk/56580/

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