Additive manufacturing of electrochemical systems and their application in bioelectronic medicine
Bioelectronic medicine is a growing field where a combination of electronic and biological systems are used to induce a therapeutic response. Despite the advancements achieved in the area with the production of retinal and cochlear implants, vagus nerve stimulators and wearable biosensors, there are...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2019
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| Online Access: | https://eprints.nottingham.ac.uk/56492/ |
| _version_ | 1848799337494085632 |
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| author | Sanjuan Alberte, Paola |
| author_facet | Sanjuan Alberte, Paola |
| author_sort | Sanjuan Alberte, Paola |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Bioelectronic medicine is a growing field where a combination of electronic and biological systems are used to induce a therapeutic response. Despite the advancements achieved in the area with the production of retinal and cochlear implants, vagus nerve stimulators and wearable biosensors, there are some challenging limitations, including a poor integration in the bioelectronic interfaces and low specificity of the outputs. In order to solve this, additive manufacturing and electrochemical approaches are explored in this work. Bioelectronic interfaces were produced in situ, growing silver microwires between CHO cells, offering an example of engineering of seamless functional interfaces controlled remotely. A model of wireless intracellular bioelectronic communication was also provided, where gold nanoparticles (AuNPs) conjugated with a redox-dependent fluorescent porphyrin were used as intracellular transducers, reducing the typical invasiveness of electronic systems and converting electronic inputs into a fluorescent output when an external electric field was applied. The last part of the investigation was to create conductive polymeric scaffolds fabricated by two-photon polymerisation (2PP) with nano- and micro-topographies to provide mechanical and electrical cues to human induced pluripotent stem cells-derived cardiomyocytes and advance their in vitro maturation state. |
| first_indexed | 2025-11-14T20:34:04Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-56492 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:34:04Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-564922025-02-28T14:28:55Z https://eprints.nottingham.ac.uk/56492/ Additive manufacturing of electrochemical systems and their application in bioelectronic medicine Sanjuan Alberte, Paola Bioelectronic medicine is a growing field where a combination of electronic and biological systems are used to induce a therapeutic response. Despite the advancements achieved in the area with the production of retinal and cochlear implants, vagus nerve stimulators and wearable biosensors, there are some challenging limitations, including a poor integration in the bioelectronic interfaces and low specificity of the outputs. In order to solve this, additive manufacturing and electrochemical approaches are explored in this work. Bioelectronic interfaces were produced in situ, growing silver microwires between CHO cells, offering an example of engineering of seamless functional interfaces controlled remotely. A model of wireless intracellular bioelectronic communication was also provided, where gold nanoparticles (AuNPs) conjugated with a redox-dependent fluorescent porphyrin were used as intracellular transducers, reducing the typical invasiveness of electronic systems and converting electronic inputs into a fluorescent output when an external electric field was applied. The last part of the investigation was to create conductive polymeric scaffolds fabricated by two-photon polymerisation (2PP) with nano- and micro-topographies to provide mechanical and electrical cues to human induced pluripotent stem cells-derived cardiomyocytes and advance their in vitro maturation state. 2019-07-22 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/56492/1/Paola%27s%20Thesis%20-%20Final%20version%20after%20corrections.pdf Sanjuan Alberte, Paola (2019) Additive manufacturing of electrochemical systems and their application in bioelectronic medicine. PhD thesis, University of Nottingham. Bioelectronics; bioelectronic medicine; electrochemistry; additive manufacturing; biomedical materials |
| spellingShingle | Bioelectronics; bioelectronic medicine; electrochemistry; additive manufacturing; biomedical materials Sanjuan Alberte, Paola Additive manufacturing of electrochemical systems and their application in bioelectronic medicine |
| title | Additive manufacturing of electrochemical systems and their application in bioelectronic medicine |
| title_full | Additive manufacturing of electrochemical systems and their application in bioelectronic medicine |
| title_fullStr | Additive manufacturing of electrochemical systems and their application in bioelectronic medicine |
| title_full_unstemmed | Additive manufacturing of electrochemical systems and their application in bioelectronic medicine |
| title_short | Additive manufacturing of electrochemical systems and their application in bioelectronic medicine |
| title_sort | additive manufacturing of electrochemical systems and their application in bioelectronic medicine |
| topic | Bioelectronics; bioelectronic medicine; electrochemistry; additive manufacturing; biomedical materials |
| url | https://eprints.nottingham.ac.uk/56492/ |