Correlation of clinical and molecular features in myotonic dystrophy type 1 (DM1)

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Correlation of clinical and molecular features in myotonic dystrophy type 1 (DM1)

Objectives: (1) To correlate RNA splicing misregulation in human DM1 vastus lateralis (VL) muscle of two DM1 splice events identified from the literature and the myotonic dystrophy deep sequencing data repository (nuclear factor I/X (NFIX) and insulin receptor (INSR)), with primary clinical outcome...

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Bibliographic Details
Main Author:	Sedehizadeh, Saam
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	RNA splicing misregulation; Myotonic dystrophy; Splicing defects; Proteomic profile; Neuromuscular decline
Online Access:	https://eprints.nottingham.ac.uk/56398/

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