Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative
A simple and efficient method was developed for the construction of the medicinally important 3-substituted-3-hydroxyoxindoleand its 3-spirocyclic derivativeswith readily available aniline derivatives as starting materials. Thishighly atom-and step-economical one-pot protocolwas carried out und...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society of Chemistry
2017
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| Online Access: | https://eprints.nottingham.ac.uk/56371/ |
| _version_ | 1848799319496327168 |
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| author | Liu, Min Zhang, Chunxia Ding, Mingruo Tang, Bencan Zhang, Fengzhi |
| author_facet | Liu, Min Zhang, Chunxia Ding, Mingruo Tang, Bencan Zhang, Fengzhi |
| author_sort | Liu, Min |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A simple and efficient method was developed for the construction of the medicinally important 3-substituted-3-hydroxyoxindoleand its 3-spirocyclic derivativeswith readily available aniline derivatives as starting materials. Thishighly atom-and step-economical one-pot protocolwas carried out undermetal-freebase-mediated conditions througha novel oxidative annulationstrategywith oxygen as the oxidant.The key intermediates were isolated and confirmed.A reasonablereaction pathway was proposed and supported by both the preliminary experiments and computational studies. |
| first_indexed | 2025-11-14T20:33:47Z |
| format | Article |
| id | nottingham-56371 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:33:47Z |
| publishDate | 2017 |
| publisher | The Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-563712019-03-27T15:34:30Z https://eprints.nottingham.ac.uk/56371/ Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative Liu, Min Zhang, Chunxia Ding, Mingruo Tang, Bencan Zhang, Fengzhi A simple and efficient method was developed for the construction of the medicinally important 3-substituted-3-hydroxyoxindoleand its 3-spirocyclic derivativeswith readily available aniline derivatives as starting materials. Thishighly atom-and step-economical one-pot protocolwas carried out undermetal-freebase-mediated conditions througha novel oxidative annulationstrategywith oxygen as the oxidant.The key intermediates were isolated and confirmed.A reasonablereaction pathway was proposed and supported by both the preliminary experiments and computational studies. The Royal Society of Chemistry 2017-08-23 Article PeerReviewed application/pdf en https://eprints.nottingham.ac.uk/56371/1/Green%20Chemistry%20manuscript%206-15.pdf Liu, Min, Zhang, Chunxia, Ding, Mingruo, Tang, Bencan and Zhang, Fengzhi (2017) Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative. Green Chemistry, 19 . pp. 4509-4514. ISSN 1463-9262 http://dx.doi.org/10.1039/c7gc01783a doi:10.1039/c7gc01783a doi:10.1039/c7gc01783a |
| spellingShingle | Liu, Min Zhang, Chunxia Ding, Mingruo Tang, Bencan Zhang, Fengzhi Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative |
| title | Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative |
| title_full | Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative |
| title_fullStr | Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative |
| title_full_unstemmed | Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative |
| title_short | Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative |
| title_sort | metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative |
| url | https://eprints.nottingham.ac.uk/56371/ https://eprints.nottingham.ac.uk/56371/ https://eprints.nottingham.ac.uk/56371/ |