Metal-free base-mediated oxidative annulation cascades to 3-substituted-3-hydroxyoxindole and its 3-spirocyclic derivative
A simple and efficient method was developed for the construction of the medicinally important 3-substituted-3-hydroxyoxindoleand its 3-spirocyclic derivativeswith readily available aniline derivatives as starting materials. Thishighly atom-and step-economical one-pot protocolwas carried out und...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Royal Society of Chemistry
2017
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| Online Access: | https://eprints.nottingham.ac.uk/56371/ |
| Summary: | A simple and efficient method was developed for the construction of the medicinally important 3-substituted-3-hydroxyoxindoleand its 3-spirocyclic derivativeswith readily available aniline derivatives as starting materials. Thishighly atom-and step-economical one-pot protocolwas carried out undermetal-freebase-mediated conditions througha novel oxidative annulationstrategywith oxygen as the oxidant.The key intermediates were isolated and confirmed.A reasonablereaction pathway was proposed and supported by both the preliminary experiments and computational studies. |
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