Investigating the contribution of kainate receptors to neurodevelopmental disorders

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Investigating the contribution of kainate receptors to neurodevelopmental disorders

Kainate receptors (KARs) are ionotropic glutamate receptors involved in presynaptic and postsynaptic neuroplasticity mechanisms. They form functional ion channels by tetrameric combinations of five different subunits (GRIK1-GRIK5, GluK1-GluK5) and they are modulated by auxiliary proteins Neto1 and N...

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Bibliographic Details
Main Author:	Koromina, Maria
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	Kainate receptors Neurodevelopmental disorders Rare variants Loss of function variants Burden analysis Cognitive impairment GRIK4 Agonist sensitivity Decay kinetics
Online Access:	https://eprints.nottingham.ac.uk/56257/

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