Generation of endogenous soluble PD-1 as a potential therapeutic strategy for cancer treatment

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Generation of endogenous soluble PD-1 as a potential therapeutic strategy for cancer treatment

The Programmed cell death (PD-1) pathway is an immunoinhibitory T cell pathway that is involved in maintaining peripheral T cell tolerance and regulation of inflammation. PD-1 binds to its ligand, PD-L1 which is expressed normally on a variety of cells and aberrantly on cancer cells. Binding of PD-1...

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Bibliographic Details
Main Author:	Wahid, Mussarat
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	Programmed cell death pathway; Tumour microenvironment; Immune homeostasis; Antibody blocking; Anti-cancer responses; Splicing decision; Immune checkpoint inhibition
Online Access:	https://eprints.nottingham.ac.uk/56199/

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