Analysis of ABCG2 pharmacology and oligomerisation by solution based fluorescence correlation spectroscopy

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Analysis of ABCG2 pharmacology and oligomerisation by solution based fluorescence correlation spectroscopy

ABCG2 is a human ATP-binding cassette (ABC) transporter. It has a broad substrate range that includes a number of small molecule drugs as well as endogenous metabolites. With its expression in barrier tissues (e.g. kidney epithelium) ABCG2 has a strong influence on pharmacokinetics in addition to ot...

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Bibliographic Details
Main Author:	Horsey, Aaron J.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	ABCG2 pharmacology; Fluorescence correlation spectroscopy; Stoichiometry; Protein complex stoichiometry; Substrate and inhibitor binding; ATP-binding cassette transporters
Online Access:	https://eprints.nottingham.ac.uk/56098/

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