Rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration
Rhodium-catalysed intramolecular arylative cyclisations of malonate esters, generating highly functionalised bicycles has been described. The key step is a known alkenyl-to-aryl 1,4-rhodium migration. The reaction is considered to proceed through regioselective carbometallation of the tethered alkyn...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2019
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| Online Access: | https://eprints.nottingham.ac.uk/55998/ |
| _version_ | 1848799252844642304 |
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| author | O'Brien, Luke |
| author_facet | O'Brien, Luke |
| author_sort | O'Brien, Luke |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Rhodium-catalysed intramolecular arylative cyclisations of malonate esters, generating highly functionalised bicycles has been described. The key step is a known alkenyl-to-aryl 1,4-rhodium migration. The reaction is considered to proceed through regioselective carbometallation of the tethered alkyne, followed by alkenyl-to-aryl 1,4-migration and subsequence intramolecular 1,2-addition to the ester moiety. Discovery and preliminary results were conducted by Dr. S. Karad. Through the use of a bisphosphine base ligand, good levels of enantiocontrol were achieved. |
| first_indexed | 2025-11-14T20:32:43Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-55998 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:32:43Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-559982025-02-28T14:22:48Z https://eprints.nottingham.ac.uk/55998/ Rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration O'Brien, Luke Rhodium-catalysed intramolecular arylative cyclisations of malonate esters, generating highly functionalised bicycles has been described. The key step is a known alkenyl-to-aryl 1,4-rhodium migration. The reaction is considered to proceed through regioselective carbometallation of the tethered alkyne, followed by alkenyl-to-aryl 1,4-migration and subsequence intramolecular 1,2-addition to the ester moiety. Discovery and preliminary results were conducted by Dr. S. Karad. Through the use of a bisphosphine base ligand, good levels of enantiocontrol were achieved. 2019-07-17 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/55998/2/Thesis%20Corrections.pdf O'Brien, Luke (2019) Rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration. MSc(Res) thesis, University of Nottingham. malonate esters; alkynes; intramolecular arylative cyclisations |
| spellingShingle | malonate esters; alkynes; intramolecular arylative cyclisations O'Brien, Luke Rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration |
| title | Rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration |
| title_full | Rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration |
| title_fullStr | Rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration |
| title_full_unstemmed | Rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration |
| title_short | Rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration |
| title_sort | rhodium-catalysed arylative cyclisations of malonate esters by 1,4-rhodium migration |
| topic | malonate esters; alkynes; intramolecular arylative cyclisations |
| url | https://eprints.nottingham.ac.uk/55998/ |