Design and evaluation of fluorescent and non-fluorescent bivalent ligands to explore their mode of action at neuropeptide Y receptors

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Design and evaluation of fluorescent and non-fluorescent bivalent ligands to explore their mode of action at neuropeptide Y receptors

Recent advances in understanding G protein coupled receptor (GPCR) pharmacology include accumulating evidence that GPCRs can form homo- and hetero- meric complexes, and that these complexes may affect physiological function and ligand pharmacology. However, the continuing controversy over the signif...

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Bibliographic Details
Main Author:	Richardson, Rachel
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2019
Subjects:	Bivalent ligands; Y1R binding site; Peptide dimer; Novel fluorescent GR231118 and BVD15 derivatives
Online Access:	https://eprints.nottingham.ac.uk/55904/

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