Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection
Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenotype can appear as small-colony variants. Although...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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2018
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| Online Access: | https://eprints.nottingham.ac.uk/54973/ |
| _version_ | 1848799092167147520 |
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| author | Askar, Mohamed Bloch, Benjamin Bayston, Roger |
| author_facet | Askar, Mohamed Bloch, Benjamin Bayston, Roger |
| author_sort | Askar, Mohamed |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenotype can appear as small-colony variants. Although genetically indistinguishable, they differ in size and antibiotic susceptibility from the parent strain and are responsible for chronic persistent infection and failure of antibiotic treatment. They can also lead to misinterpretation of results. The patient reported here underwent total knee replacement and 2 years later presented with prosthetic joint infection. Tissue samples and prosthesis taken at revision grew S lugdunensis, the majority of which were small-colony variants. Recommendations are made for their detection and identification. |
| first_indexed | 2025-11-14T20:30:10Z |
| format | Article |
| id | nottingham-54973 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:30:10Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-549732018-09-14T13:26:44Z https://eprints.nottingham.ac.uk/54973/ Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection Askar, Mohamed Bloch, Benjamin Bayston, Roger Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenotype can appear as small-colony variants. Although genetically indistinguishable, they differ in size and antibiotic susceptibility from the parent strain and are responsible for chronic persistent infection and failure of antibiotic treatment. They can also lead to misinterpretation of results. The patient reported here underwent total knee replacement and 2 years later presented with prosthetic joint infection. Tissue samples and prosthesis taken at revision grew S lugdunensis, the majority of which were small-colony variants. Recommendations are made for their detection and identification. 2018-09-30 Article PeerReviewed application/pdf en cc_by_nc_nd https://eprints.nottingham.ac.uk/54973/1/Small%20colony%201-s2.0-S2352344118300657-main.pdf Askar, Mohamed, Bloch, Benjamin and Bayston, Roger (2018) Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection. Arthroplasty Today, 4 (3). pp. 257-260. ISSN 2352-3441 https://www.sciencedirect.com/science/article/pii/S2352344118300657 doi:10.1016/j.artd.2018.06.003 doi:10.1016/j.artd.2018.06.003 |
| spellingShingle | Askar, Mohamed Bloch, Benjamin Bayston, Roger Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection |
| title | Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection |
| title_full | Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection |
| title_fullStr | Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection |
| title_full_unstemmed | Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection |
| title_short | Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection |
| title_sort | small-colony variant of staphylococcus lugdunensis in prosthetic joint infection |
| url | https://eprints.nottingham.ac.uk/54973/ https://eprints.nottingham.ac.uk/54973/ https://eprints.nottingham.ac.uk/54973/ |