Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia
Objective: To analyse Endocan-1, a biomarker of vascular endothelial related pathologies, and Placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with pre-eclampsia (PE). Methods: Case-control study conducted at São Lucas Hospital. Endocan-1 and PlGF...
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| Format: | Article |
| Language: | English |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2018
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| Online Access: | https://eprints.nottingham.ac.uk/54422/ |
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| author | Ribiero Hentchke, Marta Mistry, Hiten D. Pinheiro da Costa, Bartira Ercilia Poli-de-Figueiredo, Carlos Eduardo |
| author_facet | Ribiero Hentchke, Marta Mistry, Hiten D. Pinheiro da Costa, Bartira Ercilia Poli-de-Figueiredo, Carlos Eduardo |
| author_sort | Ribiero Hentchke, Marta |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objective: To analyse Endocan-1, a biomarker of vascular endothelial related pathologies, and Placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with pre-eclampsia (PE).
Methods: Case-control study conducted at São Lucas Hospital. Endocan-1 and PlGF levels were quantified in maternal plasma using MagPlexTH-C microspheres system and analysed by ANCOVA adjusted by BMI, gestational age and maternal age. To estimate the difference between groups, mean ratio (MR) and 95% confidence interval (CI) were calculated. Pearson correlation test was used to establish any association between Endocan-1 and PlGF levels. The null hypothesis was rejected when p<0.05.
Results: The group of patients was composed by normotensive (n=67) and patients with PE (n=50). A negative correlation between Endocan-1 and PlGF was noted in the entire group (r= -0,605; p< 0.001); as well as in the PE group (r= -0,545; p< 0.001).
Conclusion: Endocan-1 levels are increased in patients with PE and inversely correlated with PlGF levels. We suggest that it is important to analyze angiogenic and pro-inflammatory molecules concomitantly in women with PE to better understand the disease pathophysiology. Both molecules are strong competitors as a PE biomarkers and future work will examine any mechanisms connecting these factors in PE. |
| first_indexed | 2025-11-14T20:29:27Z |
| format | Article |
| id | nottingham-54422 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:29:27Z |
| publishDate | 2018 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-544222018-09-12T12:38:45Z https://eprints.nottingham.ac.uk/54422/ Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia Ribiero Hentchke, Marta Mistry, Hiten D. Pinheiro da Costa, Bartira Ercilia Poli-de-Figueiredo, Carlos Eduardo Objective: To analyse Endocan-1, a biomarker of vascular endothelial related pathologies, and Placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with pre-eclampsia (PE). Methods: Case-control study conducted at São Lucas Hospital. Endocan-1 and PlGF levels were quantified in maternal plasma using MagPlexTH-C microspheres system and analysed by ANCOVA adjusted by BMI, gestational age and maternal age. To estimate the difference between groups, mean ratio (MR) and 95% confidence interval (CI) were calculated. Pearson correlation test was used to establish any association between Endocan-1 and PlGF levels. The null hypothesis was rejected when p<0.05. Results: The group of patients was composed by normotensive (n=67) and patients with PE (n=50). A negative correlation between Endocan-1 and PlGF was noted in the entire group (r= -0,605; p< 0.001); as well as in the PE group (r= -0,545; p< 0.001). Conclusion: Endocan-1 levels are increased in patients with PE and inversely correlated with PlGF levels. We suggest that it is important to analyze angiogenic and pro-inflammatory molecules concomitantly in women with PE to better understand the disease pathophysiology. Both molecules are strong competitors as a PE biomarkers and future work will examine any mechanisms connecting these factors in PE. Federação Brasileira das Sociedades de Ginecologia e Obstetrícia 2018-07-02 Article PeerReviewed application/pdf en https://eprints.nottingham.ac.uk/54422/1/RBGO-2018-0040.R1-Original-article_MH%20%28002%29.pdf Ribiero Hentchke, Marta, Mistry, Hiten D., Pinheiro da Costa, Bartira Ercilia and Poli-de-Figueiredo, Carlos Eduardo (2018) Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia. Revista Brasileira de Ginecologia e Obstetrícia . ISSN 1806-9339 (In Press) Pregnancy-induced hypertension; Preeclampsia; Endothelial function; Biomarkers; Preeclampsia cytokines |
| spellingShingle | Pregnancy-induced hypertension; Preeclampsia; Endothelial function; Biomarkers; Preeclampsia cytokines Ribiero Hentchke, Marta Mistry, Hiten D. Pinheiro da Costa, Bartira Ercilia Poli-de-Figueiredo, Carlos Eduardo Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia |
| title | Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia |
| title_full | Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia |
| title_fullStr | Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia |
| title_full_unstemmed | Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia |
| title_short | Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia |
| title_sort | negative correlation between placental growth factor and endocan-1 in women with preeclampsia |
| topic | Pregnancy-induced hypertension; Preeclampsia; Endothelial function; Biomarkers; Preeclampsia cytokines |
| url | https://eprints.nottingham.ac.uk/54422/ |