Should data monitoring committees assess efficacy when considering safety in trails in acute stroke?
The primary role of a trials Data Monitoring Committee (DMC) is to ensure the safety of enrolled patients. In stroke trials, safety is monitored typically by comparing death and stroke specific events between treatment groups. DMCs may also have the remit for monitoring efficacy depending on the aim...
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| Format: | Article |
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Blackwell Publishing
2007
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| Online Access: | https://eprints.nottingham.ac.uk/544/ |
| _version_ | 1848790428836429824 |
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| author | Bath, Philip M.W. Gray, Laura J. Wahlgren, Nils-Gunnar |
| author_facet | Bath, Philip M.W. Gray, Laura J. Wahlgren, Nils-Gunnar |
| author_sort | Bath, Philip M.W. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The primary role of a trials Data Monitoring Committee (DMC) is to ensure the safety of enrolled patients. In stroke trials, safety is monitored typically by comparing death and stroke specific events between treatment groups. DMCs may also have the remit for monitoring efficacy depending on the aims of the trial. We hypothesised that functional outcome at end of follow-up, a measure of efficacy, is also a powerful measure of safety and tested this in a systematic review |
| first_indexed | 2025-11-14T18:12:28Z |
| format | Article |
| id | nottingham-544 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:12:28Z |
| publishDate | 2007 |
| publisher | Blackwell Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-5442020-05-04T20:28:06Z https://eprints.nottingham.ac.uk/544/ Should data monitoring committees assess efficacy when considering safety in trails in acute stroke? Bath, Philip M.W. Gray, Laura J. Wahlgren, Nils-Gunnar The primary role of a trials Data Monitoring Committee (DMC) is to ensure the safety of enrolled patients. In stroke trials, safety is monitored typically by comparing death and stroke specific events between treatment groups. DMCs may also have the remit for monitoring efficacy depending on the aims of the trial. We hypothesised that functional outcome at end of follow-up, a measure of efficacy, is also a powerful measure of safety and tested this in a systematic review Blackwell Publishing 2007-10 Article PeerReviewed Bath, Philip M.W., Gray, Laura J. and Wahlgren, Nils-Gunnar (2007) Should data monitoring committees assess efficacy when considering safety in trails in acute stroke? International Journal of Clinical Practice, 61 (10). pp. 1749-1755. stroke; clinical trial; data monitoring committees; functional outcome; efficacy; impairment |
| spellingShingle | stroke; clinical trial; data monitoring committees; functional outcome; efficacy; impairment Bath, Philip M.W. Gray, Laura J. Wahlgren, Nils-Gunnar Should data monitoring committees assess efficacy when considering safety in trails in acute stroke? |
| title | Should data monitoring committees assess efficacy when considering safety in trails in acute stroke? |
| title_full | Should data monitoring committees assess efficacy when considering safety in trails in acute stroke? |
| title_fullStr | Should data monitoring committees assess efficacy when considering safety in trails in acute stroke? |
| title_full_unstemmed | Should data monitoring committees assess efficacy when considering safety in trails in acute stroke? |
| title_short | Should data monitoring committees assess efficacy when considering safety in trails in acute stroke? |
| title_sort | should data monitoring committees assess efficacy when considering safety in trails in acute stroke? |
| topic | stroke; clinical trial; data monitoring committees; functional outcome; efficacy; impairment |
| url | https://eprints.nottingham.ac.uk/544/ |