Intestinal failure in adults: recommendations from the ESPEN Expert Groups
Background and aims: Intestinal failure (IF) is defined as “the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth”. Functionally, it may be cla...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/53997/ |
| _version_ | 1848799006220615680 |
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| author | Pironi, Loris Corcos, Olivier Forbes, Alastair Holst, Mette Joly, Francisca Jonkers, Cora Klek, Stanislaw Lal, Simon Reintam Blaser, Annika Rollins, Katie E. Sasdelli, Anna S. Schaffer, Jon Van Gossum, Andre Wanten, Geert Zanfi, Chiara Lobo, Dileep N. |
| author_facet | Pironi, Loris Corcos, Olivier Forbes, Alastair Holst, Mette Joly, Francisca Jonkers, Cora Klek, Stanislaw Lal, Simon Reintam Blaser, Annika Rollins, Katie E. Sasdelli, Anna S. Schaffer, Jon Van Gossum, Andre Wanten, Geert Zanfi, Chiara Lobo, Dileep N. |
| author_sort | Pironi, Loris |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background and aims:
Intestinal failure (IF) is defined as “the reduction of gut function below the
minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth”. Functionally, it may be classified as type I acute intestinal failure (AIF), type II prolonged AIF and type III chronic intestinal failure (CIF) The ESPEN Workshop on IF was held in Bologna, Italy, on 15-16 October 2017 and the aims of this document were to highlight the current state of the art and future directions for research in IF.
Methods:
This paper represents the opinion of experts in the field, based on current evidence. It is not a formal review, but encompasses the current evidence, with emphasis on epidemiology, classification, diagnosis and management.
Results:
IF is the rarest form of organ failure and can result from a variety of conditions that affect gastrointestinal anatomy and function adversely. Assessment, diagnosis, and short and long-term management involves a multidisciplinary team with diverse expertise in the field that aims to reduce complications, increase life expectancy and improve quality of life in patients.
Conclusions:
Both AIF and CIF are relatively rare conditions and most of the published work presents evidence from small, single-centre studies. Much remains to be investigated to improve the diagnosis and management of IF and future studies should rely on multidisciplinary, multicentre and multinational collaborations that gather data from large cohorts of patients. Emphasis should also be placed on partnership with patients, carers and government agencies in order to improve the quality of research that focuses on patient-centred outcomes that will help to improve both outcomes and quality of life in patients with this devastating condition. |
| first_indexed | 2025-11-14T20:28:48Z |
| format | Article |
| id | nottingham-53997 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:28:48Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-539972019-08-18T04:30:17Z https://eprints.nottingham.ac.uk/53997/ Intestinal failure in adults: recommendations from the ESPEN Expert Groups Pironi, Loris Corcos, Olivier Forbes, Alastair Holst, Mette Joly, Francisca Jonkers, Cora Klek, Stanislaw Lal, Simon Reintam Blaser, Annika Rollins, Katie E. Sasdelli, Anna S. Schaffer, Jon Van Gossum, Andre Wanten, Geert Zanfi, Chiara Lobo, Dileep N. Background and aims: Intestinal failure (IF) is defined as “the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth”. Functionally, it may be classified as type I acute intestinal failure (AIF), type II prolonged AIF and type III chronic intestinal failure (CIF) The ESPEN Workshop on IF was held in Bologna, Italy, on 15-16 October 2017 and the aims of this document were to highlight the current state of the art and future directions for research in IF. Methods: This paper represents the opinion of experts in the field, based on current evidence. It is not a formal review, but encompasses the current evidence, with emphasis on epidemiology, classification, diagnosis and management. Results: IF is the rarest form of organ failure and can result from a variety of conditions that affect gastrointestinal anatomy and function adversely. Assessment, diagnosis, and short and long-term management involves a multidisciplinary team with diverse expertise in the field that aims to reduce complications, increase life expectancy and improve quality of life in patients. Conclusions: Both AIF and CIF are relatively rare conditions and most of the published work presents evidence from small, single-centre studies. Much remains to be investigated to improve the diagnosis and management of IF and future studies should rely on multidisciplinary, multicentre and multinational collaborations that gather data from large cohorts of patients. Emphasis should also be placed on partnership with patients, carers and government agencies in order to improve the quality of research that focuses on patient-centred outcomes that will help to improve both outcomes and quality of life in patients with this devastating condition. Elsevier 2018-08-18 Article PeerReviewed application/pdf en cc_by_nc_nd https://eprints.nottingham.ac.uk/53997/1/YCLNU-D-18-00804.pdf Pironi, Loris, Corcos, Olivier, Forbes, Alastair, Holst, Mette, Joly, Francisca, Jonkers, Cora, Klek, Stanislaw, Lal, Simon, Reintam Blaser, Annika, Rollins, Katie E., Sasdelli, Anna S., Schaffer, Jon, Van Gossum, Andre, Wanten, Geert, Zanfi, Chiara and Lobo, Dileep N. (2018) Intestinal failure in adults: recommendations from the ESPEN Expert Groups. Clinical Nutrition . ISSN 1532-1983 intestinal failure; short bowel syndrome; definitions; management; acute; chronic; https://www.sciencedirect.com/science/article/pii/S0261561418312536?via%3Dihub doi:10.1016/j.clnu.2018.07.036 doi:10.1016/j.clnu.2018.07.036 |
| spellingShingle | intestinal failure; short bowel syndrome; definitions; management; acute; chronic; Pironi, Loris Corcos, Olivier Forbes, Alastair Holst, Mette Joly, Francisca Jonkers, Cora Klek, Stanislaw Lal, Simon Reintam Blaser, Annika Rollins, Katie E. Sasdelli, Anna S. Schaffer, Jon Van Gossum, Andre Wanten, Geert Zanfi, Chiara Lobo, Dileep N. Intestinal failure in adults: recommendations from the ESPEN Expert Groups |
| title | Intestinal failure in adults: recommendations from the ESPEN Expert Groups |
| title_full | Intestinal failure in adults: recommendations from the ESPEN Expert Groups |
| title_fullStr | Intestinal failure in adults: recommendations from the ESPEN Expert Groups |
| title_full_unstemmed | Intestinal failure in adults: recommendations from the ESPEN Expert Groups |
| title_short | Intestinal failure in adults: recommendations from the ESPEN Expert Groups |
| title_sort | intestinal failure in adults: recommendations from the espen expert groups |
| topic | intestinal failure; short bowel syndrome; definitions; management; acute; chronic; |
| url | https://eprints.nottingham.ac.uk/53997/ https://eprints.nottingham.ac.uk/53997/ https://eprints.nottingham.ac.uk/53997/ |