Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin – The case of the fungal metabolite atromentin

Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin – The case of the fungal metabolite atromentin

Many small molecules of food origin may effect human health but lack an adequate description of their biological activity. To fill this knowledge gap, a first-line workflow is needed to assign putative functions, rank the endpoints for testing and guide wet-lab experiments. In this framework, the id...

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Bibliographic Details
Main Authors: Dellafiora, Luca, Aichinger, Georg, Geib, Elena, Sánchez-Barrionuevo, Leyre, Brock, Matthias, Cánovas, David, Dall'Asta, Chiara, Marko, Doris
Format: Article
Language:English
Published: Elsevier 2019
Subjects:
Atromentin; Target fishing; Estrogenic activity; Fungal metabolite; Activity assignment; 17-β-Hydroxysteroid dehydrogenase
Online Access:https://eprints.nottingham.ac.uk/53975/

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