Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations
The “smart” amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using a commercially available amine transaminase, ATA256. The methodology enables both screening and preparative...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018
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| Online Access: | https://eprints.nottingham.ac.uk/53766/ |
| _version_ | 1848798986809376768 |
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| author | Gomm, Andrew Grigoriou, Stylianos Peel, Christopher Ryan, James Mujtaba, Nafees Clarke, Thomas Kulcinskaja, Evelina O'Reilly, Elaine |
| author_facet | Gomm, Andrew Grigoriou, Stylianos Peel, Christopher Ryan, James Mujtaba, Nafees Clarke, Thomas Kulcinskaja, Evelina O'Reilly, Elaine |
| author_sort | Gomm, Andrew |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The “smart” amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using a commercially available amine transaminase, ATA256. The methodology enables both screening and preparative‐scale biotransformations to be performed with a single enzyme and simplifies the generation of sp3‐rich small‐molecule libraries. |
| first_indexed | 2025-11-14T20:28:29Z |
| format | Article |
| id | nottingham-53766 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:28:29Z |
| publishDate | 2018 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-537662019-07-06T04:30:18Z https://eprints.nottingham.ac.uk/53766/ Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations Gomm, Andrew Grigoriou, Stylianos Peel, Christopher Ryan, James Mujtaba, Nafees Clarke, Thomas Kulcinskaja, Evelina O'Reilly, Elaine The “smart” amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using a commercially available amine transaminase, ATA256. The methodology enables both screening and preparative‐scale biotransformations to be performed with a single enzyme and simplifies the generation of sp3‐rich small‐molecule libraries. Wiley 2018-07-06 Article PeerReviewed application/pdf en https://eprints.nottingham.ac.uk/53766/1/Smart%20anime%20donors.pdf Gomm, Andrew, Grigoriou, Stylianos, Peel, Christopher, Ryan, James, Mujtaba, Nafees, Clarke, Thomas, Kulcinskaja, Evelina and O'Reilly, Elaine (2018) Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations. European Journal of Organic Chemistry . ISSN 1099-0690 https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201800799 doi:10.1002/ejoc.201800799 doi:10.1002/ejoc.201800799 |
| spellingShingle | Gomm, Andrew Grigoriou, Stylianos Peel, Christopher Ryan, James Mujtaba, Nafees Clarke, Thomas Kulcinskaja, Evelina O'Reilly, Elaine Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations |
| title | Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations |
| title_full | Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations |
| title_fullStr | Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations |
| title_full_unstemmed | Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations |
| title_short | Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations |
| title_sort | application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations |
| url | https://eprints.nottingham.ac.uk/53766/ https://eprints.nottingham.ac.uk/53766/ https://eprints.nottingham.ac.uk/53766/ |