Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules
Objectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population. Materials and methods: This study was nested within a randomised controlled t...
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| Format: | Article |
| Language: | English |
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Elsevier
2018
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| Online Access: | https://eprints.nottingham.ac.uk/53572/ |
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| author | Clark, Marcia E. Bedford, Laura E. Young, Ben Robertson, John F.R. das Nair, Roshan Vedhara, Kavita Littleford, Roberta Sullivan, Francis M. Mair, Frances S. Schembri, Stuart Rauchhaus, Petra Kendrick, Denise |
| author_facet | Clark, Marcia E. Bedford, Laura E. Young, Ben Robertson, John F.R. das Nair, Roshan Vedhara, Kavita Littleford, Roberta Sullivan, Francis M. Mair, Frances S. Schembri, Stuart Rauchhaus, Petra Kendrick, Denise |
| author_sort | Clark, Marcia E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population.
Materials and methods: This study was nested within a randomised controlled trial of a blood test (Early CDT®-Lung test), followed by a chest x-ray and serial CT-scanning of those with a positive blood test for early detection of lung cancer (ECLS Study). Trial participants with a positive Early CDT®-Lung test were invited to participate (n=338) and those agreeing completed questionnaires assessing psychological outcomes at 1, 3 and 6 months following trial recruitment. Responses of individuals with pulmonary nodules on their first CT scan were compared to those without (classified as normal CT) at 3 and 6 months follow-up using random effects regression models to account for multiple observations per participant, with loge transformation of data where modelling assumptions were not met.
Results: There were no statistically significant differences between the nodule and normal CT groups in affect, lung cancer worry, health anxiety, illness perceptions, lung cancer risk perception or intrusive thoughts at 3 or 6 months post-recruitment. The nodule group had statistically significantly fewer avoidance symptoms compared to the normal CT group at 3 months (impact of events scale avoidance (IES-A) difference between means -1.99, 95%CI -4.18, 0.21) than at 6 months (IES-A difference between means 0.88, 95%CI -1.32, 3.08; p-value for change over time =0.003) with similar findings using loge transformed data.
Conclusion: A diagnosis of pulmonary nodules following an Early CDT®-Lung test and CT scan did not appear to result in adverse psychological responses compared to those with a normal CT scan. |
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| format | Article |
| id | nottingham-53572 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:28:02Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-535722019-08-03T04:30:15Z https://eprints.nottingham.ac.uk/53572/ Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules Clark, Marcia E. Bedford, Laura E. Young, Ben Robertson, John F.R. das Nair, Roshan Vedhara, Kavita Littleford, Roberta Sullivan, Francis M. Mair, Frances S. Schembri, Stuart Rauchhaus, Petra Kendrick, Denise Objectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population. Materials and methods: This study was nested within a randomised controlled trial of a blood test (Early CDT®-Lung test), followed by a chest x-ray and serial CT-scanning of those with a positive blood test for early detection of lung cancer (ECLS Study). Trial participants with a positive Early CDT®-Lung test were invited to participate (n=338) and those agreeing completed questionnaires assessing psychological outcomes at 1, 3 and 6 months following trial recruitment. Responses of individuals with pulmonary nodules on their first CT scan were compared to those without (classified as normal CT) at 3 and 6 months follow-up using random effects regression models to account for multiple observations per participant, with loge transformation of data where modelling assumptions were not met. Results: There were no statistically significant differences between the nodule and normal CT groups in affect, lung cancer worry, health anxiety, illness perceptions, lung cancer risk perception or intrusive thoughts at 3 or 6 months post-recruitment. The nodule group had statistically significantly fewer avoidance symptoms compared to the normal CT group at 3 months (impact of events scale avoidance (IES-A) difference between means -1.99, 95%CI -4.18, 0.21) than at 6 months (IES-A difference between means 0.88, 95%CI -1.32, 3.08; p-value for change over time =0.003) with similar findings using loge transformed data. Conclusion: A diagnosis of pulmonary nodules following an Early CDT®-Lung test and CT scan did not appear to result in adverse psychological responses compared to those with a normal CT scan. Elsevier 2018-10-31 Article PeerReviewed application/pdf en https://eprints.nottingham.ac.uk/53572/1/Clark%20Lung%20Cancer%202018%20AAM.pdf Clark, Marcia E., Bedford, Laura E., Young, Ben, Robertson, John F.R., das Nair, Roshan, Vedhara, Kavita, Littleford, Roberta, Sullivan, Francis M., Mair, Frances S., Schembri, Stuart, Rauchhaus, Petra and Kendrick, Denise (2018) Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules. Lung Cancer, 124 . pp. 160-167. ISSN 0169-5002 Pulmonary nodules; Lung cancer screening; Psychological impact http://dx.doi.org/10.1016/j.lungcan.2018.08.001 doi:10.1016/j.lungcan.2018.08.001 doi:10.1016/j.lungcan.2018.08.001 |
| spellingShingle | Pulmonary nodules; Lung cancer screening; Psychological impact Clark, Marcia E. Bedford, Laura E. Young, Ben Robertson, John F.R. das Nair, Roshan Vedhara, Kavita Littleford, Roberta Sullivan, Francis M. Mair, Frances S. Schembri, Stuart Rauchhaus, Petra Kendrick, Denise Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules |
| title | Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules |
| title_full | Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules |
| title_fullStr | Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules |
| title_full_unstemmed | Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules |
| title_short | Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules |
| title_sort | lung cancer ct screening: psychological responses in the presence and absence of pulmonary nodules |
| topic | Pulmonary nodules; Lung cancer screening; Psychological impact |
| url | https://eprints.nottingham.ac.uk/53572/ https://eprints.nottingham.ac.uk/53572/ https://eprints.nottingham.ac.uk/53572/ |