Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters

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Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters

The enantioselective synthesis of highly functionalized chiral cyclopent-2-enones by the reaction of alkynyl malonate esters with arylboronic acids is described. These desymmetrizing arylative cyclizations are catalyzed by a chiral phosphinooxazoline–nickel complex, and cyclization is enabled by the...

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Bibliographic Details
Main Authors:	Karad, Somnath Narayan, Panchal, Heena, Clarke, Christopher, Lewis, William, Lam, Hon Wai
Format:	Article
Language:	English
Published:	Wiley-VCH Verlag 2018
Subjects:	asymmetric catalysis; carbocycles; cyclization; isomerization; nickel
Online Access:	https://eprints.nottingham.ac.uk/53504/

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