Temperature-ramped 129Xe spin-exchange optical pumping
We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode 129Xe hyperpolarizer utilizing three key temperature regimes: (i) “hot”where the 129Xe hyperpolarization rate is maximal, (ii) “warm”-where the 129Xe hyperpolarization approaches unity,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2018
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| Online Access: | https://eprints.nottingham.ac.uk/53437/ |
| _version_ | 1848798940955148288 |
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| author | Nikolaou, Panayiotis Coffey, Aaron M. Barlow, Michael J. Rosen, Matthew S. Goodson, Boyd M. Chekmenev, Eduard Y. |
| author_facet | Nikolaou, Panayiotis Coffey, Aaron M. Barlow, Michael J. Rosen, Matthew S. Goodson, Boyd M. Chekmenev, Eduard Y. |
| author_sort | Nikolaou, Panayiotis |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode 129Xe hyperpolarizer utilizing three key temperature regimes: (i) “hot”where the 129Xe hyperpolarization rate is maximal, (ii) “warm”-where the 129Xe hyperpolarization approaches unity, and (iii) “cool” where hyperpolarized 129Xe gas is transferred into a Tedlar bag with low Rb content (<5 ng per ∼1 L dose) suitable for human imaging applications. Unlike with the conventional approach of batch-mode SEOP, here all three temperature regimes may be operated under continuous high-power (170 W) laser irradiation, and hyperpolarized 129Xe gas is delivered without the need for a cryocollection step. The variable-temperature approach increased the SEOP rate by more than 2-fold compared to the constant-temperature polarization rate (e.g., giving effective values for the exponential buildup constant γSEOP of 62.5 ± 3.7 × 10−3 min−1 vs 29.9 ± 1.2 × 10−3 min−1) while achieving nearly the same maximum %PXe value (88.0 ± 0.8% vs 90.1% ± 0.8%, for a 500 Torr (67 kPa) Xe cell loadingcorresponding to nuclear magnetic resonance/magnetic resonance imaging (NMR/MRI) enhancements of ∼3.1 × 105 and ∼2.32 × 108 at the relevant fields for clinical imaging and HP 129Xe production of 3 T and 4 mT, respectively); moreover, the intercycle “dead” time was also significantly decreased. The higher-throughput TR-SEOP approach can be implemented without sacrificing the level of 129Xe hyperpolarization
or the experimental stability for automation-making this approach beneficial for improving the overall 129Xe production rate in clinical settings. |
| first_indexed | 2025-11-14T20:27:46Z |
| format | Article |
| id | nottingham-53437 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:27:46Z |
| publishDate | 2018 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-534372018-08-23T10:24:19Z https://eprints.nottingham.ac.uk/53437/ Temperature-ramped 129Xe spin-exchange optical pumping Nikolaou, Panayiotis Coffey, Aaron M. Barlow, Michael J. Rosen, Matthew S. Goodson, Boyd M. Chekmenev, Eduard Y. We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode 129Xe hyperpolarizer utilizing three key temperature regimes: (i) “hot”where the 129Xe hyperpolarization rate is maximal, (ii) “warm”-where the 129Xe hyperpolarization approaches unity, and (iii) “cool” where hyperpolarized 129Xe gas is transferred into a Tedlar bag with low Rb content (<5 ng per ∼1 L dose) suitable for human imaging applications. Unlike with the conventional approach of batch-mode SEOP, here all three temperature regimes may be operated under continuous high-power (170 W) laser irradiation, and hyperpolarized 129Xe gas is delivered without the need for a cryocollection step. The variable-temperature approach increased the SEOP rate by more than 2-fold compared to the constant-temperature polarization rate (e.g., giving effective values for the exponential buildup constant γSEOP of 62.5 ± 3.7 × 10−3 min−1 vs 29.9 ± 1.2 × 10−3 min−1) while achieving nearly the same maximum %PXe value (88.0 ± 0.8% vs 90.1% ± 0.8%, for a 500 Torr (67 kPa) Xe cell loadingcorresponding to nuclear magnetic resonance/magnetic resonance imaging (NMR/MRI) enhancements of ∼3.1 × 105 and ∼2.32 × 108 at the relevant fields for clinical imaging and HP 129Xe production of 3 T and 4 mT, respectively); moreover, the intercycle “dead” time was also significantly decreased. The higher-throughput TR-SEOP approach can be implemented without sacrificing the level of 129Xe hyperpolarization or the experimental stability for automation-making this approach beneficial for improving the overall 129Xe production rate in clinical settings. American Chemical Society 2018-08-19 Article PeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/53437/1/ac501537w.pdf Nikolaou, Panayiotis, Coffey, Aaron M., Barlow, Michael J., Rosen, Matthew S., Goodson, Boyd M. and Chekmenev, Eduard Y. (2018) Temperature-ramped 129Xe spin-exchange optical pumping. Analytical Chemistry, 86 (16). pp. 8206-8212. ISSN 1520-6882 https://pubs.acs.org/doi/10.1021/ac501537w doi:10.1021/ac501537w doi:10.1021/ac501537w |
| spellingShingle | Nikolaou, Panayiotis Coffey, Aaron M. Barlow, Michael J. Rosen, Matthew S. Goodson, Boyd M. Chekmenev, Eduard Y. Temperature-ramped 129Xe spin-exchange optical pumping |
| title | Temperature-ramped 129Xe spin-exchange optical pumping |
| title_full | Temperature-ramped 129Xe spin-exchange optical pumping |
| title_fullStr | Temperature-ramped 129Xe spin-exchange optical pumping |
| title_full_unstemmed | Temperature-ramped 129Xe spin-exchange optical pumping |
| title_short | Temperature-ramped 129Xe spin-exchange optical pumping |
| title_sort | temperature-ramped 129xe spin-exchange optical pumping |
| url | https://eprints.nottingham.ac.uk/53437/ https://eprints.nottingham.ac.uk/53437/ https://eprints.nottingham.ac.uk/53437/ |