The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points

QR Code

The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points

Loss of muscle mass and insulin sensitivity are common phenotypic traits of immobilisation and increased inflammatory burden. The suppression of muscle protein synthesis is the primary driver of muscle mass loss in human immobilisation, and includes blunting of post‐prandial increases in muscle prot...

Full description

Bibliographic Details
Main Authors:	Crossland, Hannah, Skirrow, Sarah, Puthucheary, Zudin A., Constantin-Teodosiu, Dumitru, Greenhaff, Paul L.
Format:	Article
Language:	English
Published:	Wiley 2018
Subjects:	Carbohydrate metabolism; Muscle fuel selection; Inactivity; Bed-rest; Muscle atrophy; Muscle protein synthesis; Muscle protein breakdown
Online Access:	https://eprints.nottingham.ac.uk/53387/

Similar Items

The impacts of bed rest and acute trauma on muscle metabolic health in humans
by: Shur, Natalie F.
Published: (2024)

Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats
by: Crossland, Hannah, et al.
Published: (2017)

A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: a proof-of-concept study
by: Crossland, Hannah, et al.
Published: (2017)

Muscle architectural and physiological responses to immobilisation: impact of age and obesity
by: Ali, Arfan M.
Published: (2020)

Development and application of minimally invasive stable isotope tracers’ measures of muscle mass and muscle protein synthesis/breakdown: insights into ageing skeletal muscle
by: Cegielski, Jessica
Published: (2020)

Development and application of novel stable isotopic approaches to study human skeletal muscle in response to exercise and ageing
by: Brook, Matthew
Published: (2017)

Exploring mechanisms of disuse atrophy and optimal rehabilitation strategies for the restoration of muscle mass, structure & function
by: Inns, Thomas Benjamin
Published: (2023)

Nutrient modulation in the management of disease-induced muscle wasting: evidence from human studies
by: Brook, Matthew S., et al.
Published: (2017)

Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent
by: Porter, Craig, et al.
Published: (2017)

Investigating a novel exercise training strategy on neuromuscular health
by: Ely, Isabel A
Published: (2020)

The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells
by: Crossland, Hannah, et al.
Published: (2018)

Pain behaviour, locomotor activity, inflammation and muscle metabolic dysregulation in pre-clinical animal models of OA and RA and the impact of PPARɣ agonism intervention
by: Casanova, Nuria
Published: (2019)

Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown and insulin resistance- a qualitative review
by: Rudrappa, Supreeth S., et al.
Published: (2016)

Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men
by: Atherton, Philip J., et al.
Published: (2016)

Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions
by: Phillips, Bethan E., et al.
Published: (2014)

Human muscle weakness and fatigue: the effects of disuse, age and exercise
by: White, Michael J.
Published: (1987)

The role of skeletal muscle in the initiation and progression of knee osteoarthritis
by: Tonge, Daniel Paul
Published: (2010)

A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men
by: Mitchell, William Kyle, et al.
Published: (2015)

Acute disuse muscle atrophy in health and disease: an investigation of the timecourse, functional effects and a potential treatment strategy
by: Hardy, Edward John Oliver
Published: (2023)

Very low-energy diets in overweight-to-obese, middle-aged men with type two diabetes mellitus or prediabetes: the musculoskeletal and metabolic effects of adjunct high-intensity interval training
by: Ardavani, Arash
Published: (2024)

The impact of leucine-enriched whey protein on skeletal muscle anabolism
by: Ely, Isabel
Published: (2024)

The role of the vitamin D receptor in skeletal muscle protein metabolism
by: Bass, Joseph
Published: (2017)

A Comparison of Linear and Undulating Periodization for Improving Muscular Strength and Strength Endurance in Men
by: Niknafs, Saba
Published: (2008)

Investigation of muscle mass and metabolic regulation in human volunteers: the impact of resistance exercise, pharmacological intervention and obesity
by: Taylor, Tariq Yaqub
Published: (2020)

Skeletal muscle remodeling in response to eccentric vs. concentric loading: morphological, molecular, and metabolic adaptations
by: Franchi, Martino V., et al.
Published: (2017)

The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply
by: Mitchell, W. Kyle, et al.
Published: (2015)

Does muscle size matter?: The relationship between muscle size and strength in children with cerebral palsy
by: Reid, S., et al.
Published: (2015)

The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans
by: Wilkinson, Daniel J., et al.
Published: (2018)

Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function.
by: Murton, Andrew J., et al.
Published: (2015)

Exploring the role of mitochondria in the changes seen in overall skeletal muscle health associated with ageing and cancer
by: Hatt, Jacob
Published: (2021)

Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle
by: Franchi, Martino V., et al.
Published: (2015)

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice
by: Barns, M., et al.
Published: (2014)

The heterogeneity of the functional, metabolic, and molecular responses of skeletal muscle and clinical adaptations to exercise training in pre-clinical and human models
by: Farrash, Wesam
Published: (2020)

Separate assessment of gluteus medius and minimus: B-mode or M-mode ultrasound?
by: Dieterich, Angela, et al.
Published: (2014)

Classification of ankle joint movements based on surface electromyography signals
by: Al-Quraishi, Maged Saleh Saeed
Published: (2015)

Effect of prototype armrest on comfort and muscle activity among selected male university motorcyclists during prolonged riding process
by: Alias, Ayuni Nabilah
Published: (2015)

Evaluation of motorcycle seat with lumbar support massager in reducing discomfort and maintaining spinal posture among traffic police riders
by: Mohammad Yusof, Nur Athirah Diyana
Published: (2021)

Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery
by: Varadhan, Krishna K., et al.
Published: (2017)

Utility of the precision cut lung slice model to investigate airway smooth muscle contraction
by: Fox, Jane
Published: (2011)

Characterisation of the anabolic effects of leucine on primary chicken muscle cells and murine C2C12 muscle cells
by: Elsaied, Nashwa
Published: (2021)