The Meisenheimer complex as a paradigm in drug discovery: reversible covalent inhibition through C67 of the ATP binding site of PLK1

The Meisenheimer complex as a paradigm in drug discovery: reversible covalent inhibition through C67 of the ATP binding site of PLK1

The polo kinase family are important oncology targets that act in regulating entry into and progression through mitosis. Structure-guided discovery of a new class of inhibitors of Polo-like kinase 1 (PLK1) catalytic activity that interact with Cys67 of the ATP binding site is described. Compounds co...

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Bibliographic Details
Main Authors: Pearson, Russell J., Blake, David G., Mezna, Mokdad, Fischer, Peter M., Westwood, Nicholas J., McInnes, Campbell
Format: Article
Language:English
Published: Elsevier 2018
Online Access:https://eprints.nottingham.ac.uk/53384/

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