A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia

The adaptive cellular response to low oxygen tensions is mediated by the hypoxia inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and β subunits. Prolonged HIF expression is a key contributor to cellular transformation, tumourigenesis and metastasis. As s...

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Bibliographic Details
Main Authors: Foxler, Daniel E., Bridge, Katherine S., Foster, John G., Grevitt, Paul, Curry, Sean, Shah, Kunal M., Davidson, Kathryn M., Nagano, Ai, Gadaleta, Emanuela, Rhys, Hefin I., Kennedy, Paul T., Hermida, Miguel A., Chang, Ting-Yu, Shaw, Peter E., Reynolds, Louise E., McKay, Tristan R., Wang, Hsei- Wei, Ribeiro, Paulo S., Plevin, Michael J., Lagos, Dimitris, Lemoine, Nicholas R., Rajan, Prabhakar, Graham, Trevor A., Chelala, Claude, Hodivala-Dilke, Kairbaan M., Spendlove, Ian, Sharp, Tyson V.
Format: Article
Published: Wiley Open Access 2018
Subjects:
Adaptive hypoxic response; HIF-1; LIMD1; lung cancer; Tumour suppressor
Online Access:https://eprints.nottingham.ac.uk/53241/

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