Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives
The patterns of 5-methylcytosine (5mC) and its oxidized derivatives, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine (5caC) are reportedly altered in a range of cancers. Likewise, Wilms’ Tumor protein 1 (WT1), a transcription factor essential for urogenital, epicardium, and kidney...
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| Format: | Article |
| Language: | English |
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Frontiers Media
2018
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| Online Access: | https://eprints.nottingham.ac.uk/53177/ |
| _version_ | 1848798894530494464 |
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| author | Ramsawhook, Ashley Ruzov, Alexey Coyle, Beth |
| author_facet | Ramsawhook, Ashley Ruzov, Alexey Coyle, Beth |
| author_sort | Ramsawhook, Ashley |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The patterns of 5-methylcytosine (5mC) and its oxidized derivatives, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine (5caC) are reportedly altered in a range of cancers. Likewise, Wilms’ Tumor protein 1 (WT1), a transcription factor essential for urogenital, epicardium, and kidney development exhibits aberrant expression in multiple tumors. Interestingly, WT1 directly interacts with TET proteins that catalyze the enzymatic oxidation of 5mC and exhibits high affinity for 5caC-containing DNA substrates in vitro. Here we review recent developments in the fields of Tet-dependent 5mC oxidation and WT1 biology and explore potential perspectives for studying the interplay between TETs and WT1 in brain tumors. |
| first_indexed | 2025-11-14T20:27:01Z |
| format | Article |
| id | nottingham-53177 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T20:27:01Z |
| publishDate | 2018 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-531772018-07-27T12:29:36Z https://eprints.nottingham.ac.uk/53177/ Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives Ramsawhook, Ashley Ruzov, Alexey Coyle, Beth The patterns of 5-methylcytosine (5mC) and its oxidized derivatives, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine (5caC) are reportedly altered in a range of cancers. Likewise, Wilms’ Tumor protein 1 (WT1), a transcription factor essential for urogenital, epicardium, and kidney development exhibits aberrant expression in multiple tumors. Interestingly, WT1 directly interacts with TET proteins that catalyze the enzymatic oxidation of 5mC and exhibits high affinity for 5caC-containing DNA substrates in vitro. Here we review recent developments in the fields of Tet-dependent 5mC oxidation and WT1 biology and explore potential perspectives for studying the interplay between TETs and WT1 in brain tumors. Frontiers Media 2018-03-22 Article PeerReviewed application/pdf en cc_by https://eprints.nottingham.ac.uk/53177/1/fcell-06-00026.pdf Ramsawhook, Ashley, Ruzov, Alexey and Coyle, Beth (2018) Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives. Frontiers in Cell and Developmental Biology, 6 . p. 26. ISSN 2296-634X Wilms’ Tumor 1 DNA demethylation epigenetics brain tumors glioblastoma ependymoma medullobastoma TET proteins https://www.frontiersin.org/articles/10.3389/fcell.2018.00026/full doi:10.3389/fcell.2018.00026 doi:10.3389/fcell.2018.00026 |
| spellingShingle | Wilms’ Tumor 1 DNA demethylation epigenetics brain tumors glioblastoma ependymoma medullobastoma TET proteins Ramsawhook, Ashley Ruzov, Alexey Coyle, Beth Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives |
| title | Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives |
| title_full | Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives |
| title_fullStr | Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives |
| title_full_unstemmed | Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives |
| title_short | Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives |
| title_sort | wilms' tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives |
| topic | Wilms’ Tumor 1 DNA demethylation epigenetics brain tumors glioblastoma ependymoma medullobastoma TET proteins |
| url | https://eprints.nottingham.ac.uk/53177/ https://eprints.nottingham.ac.uk/53177/ https://eprints.nottingham.ac.uk/53177/ |