Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications
A Passerini three-component polymerization was performed for the synthesis of amphiphilic star-shaped block copolymers with hydrophobic cores and hydrophilic coronae. The degree of polymerization of the hydrophobic core was varied from 5 to 10 repeating units, and the side chain ends were conjugated...
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| Format: | Article |
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American Chemical Society
2018
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| Online Access: | https://eprints.nottingham.ac.uk/53154/ |
| _version_ | 1848798889105162240 |
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| author | Oelmann, Stefan Travanut, Alessandra Barther, Dennis Romero, Manuel Howdle, Steven M. Alexander, Cameron Meier, Michael A.R. |
| author_facet | Oelmann, Stefan Travanut, Alessandra Barther, Dennis Romero, Manuel Howdle, Steven M. Alexander, Cameron Meier, Michael A.R. |
| author_sort | Oelmann, Stefan |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A Passerini three-component polymerization was performed for the synthesis of amphiphilic star-shaped block copolymers with hydrophobic cores and hydrophilic coronae. The degree of polymerization of the hydrophobic core was varied from 5 to 10 repeating units, and the side chain ends were conjugated by performing a Passerini-3CR with PEG-isocyanide and PEG-aldehyde (950 g/mol). The resulting amphiphilic star-shaped block copolymers contained thioether groups, which could be oxidized to sulfones in order to further tune the polarity of the polymer chains. The ability of the amphiphilic copolymers to act as unimolecular micellar encapsulants was tested with the water-insoluble dye Orange II, the water-soluble dye Para Red and the macrolide antibiotic azithromycin. The results showed that the new copolymers were able to retain drug cargo at pH levels corresponding to circulating blood and selectively release therapeutically effective doses of antibiotic as measured by bacterial cell kill. The polymers were also well-tolerated by differentiated THP-1 macrophages in the absence of encapsulated drugs. |
| first_indexed | 2025-11-14T20:26:56Z |
| format | Article |
| id | nottingham-53154 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:26:56Z |
| publishDate | 2018 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-531542020-05-04T19:39:31Z https://eprints.nottingham.ac.uk/53154/ Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications Oelmann, Stefan Travanut, Alessandra Barther, Dennis Romero, Manuel Howdle, Steven M. Alexander, Cameron Meier, Michael A.R. A Passerini three-component polymerization was performed for the synthesis of amphiphilic star-shaped block copolymers with hydrophobic cores and hydrophilic coronae. The degree of polymerization of the hydrophobic core was varied from 5 to 10 repeating units, and the side chain ends were conjugated by performing a Passerini-3CR with PEG-isocyanide and PEG-aldehyde (950 g/mol). The resulting amphiphilic star-shaped block copolymers contained thioether groups, which could be oxidized to sulfones in order to further tune the polarity of the polymer chains. The ability of the amphiphilic copolymers to act as unimolecular micellar encapsulants was tested with the water-insoluble dye Orange II, the water-soluble dye Para Red and the macrolide antibiotic azithromycin. The results showed that the new copolymers were able to retain drug cargo at pH levels corresponding to circulating blood and selectively release therapeutically effective doses of antibiotic as measured by bacterial cell kill. The polymers were also well-tolerated by differentiated THP-1 macrophages in the absence of encapsulated drugs. American Chemical Society 2018-06-05 Article PeerReviewed Oelmann, Stefan, Travanut, Alessandra, Barther, Dennis, Romero, Manuel, Howdle, Steven M., Alexander, Cameron and Meier, Michael A.R. (2018) Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications. Biomacromolecules . ISSN 1526-4602 http://dx.doi.org/10.1021/acs.biomac.8b00592 doi:10.1021/acs.biomac.8b00592 doi:10.1021/acs.biomac.8b00592 |
| spellingShingle | Oelmann, Stefan Travanut, Alessandra Barther, Dennis Romero, Manuel Howdle, Steven M. Alexander, Cameron Meier, Michael A.R. Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications |
| title | Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications |
| title_full | Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications |
| title_fullStr | Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications |
| title_full_unstemmed | Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications |
| title_short | Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications |
| title_sort | biocompatible unimolecular micelles obtained via the passerini reaction as versatile nanocarriers for potential medical applications |
| url | https://eprints.nottingham.ac.uk/53154/ https://eprints.nottingham.ac.uk/53154/ https://eprints.nottingham.ac.uk/53154/ |