Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway
The mechanisms of efficacy for fecal microbiota# transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. Furthermore, the potential implications for host ph...
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| Format: | Article |
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Taylor & Francis
2018
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| Online Access: | https://eprints.nottingham.ac.uk/53079/ |
| _version_ | 1848798872411832320 |
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| author | Monaghan, Tanya M. Mullish, Benjamin H. Patterson, Jordan Wong, Gane K.S. Marchesi, Julian R. Xu, Huiping Tahseen, Jilani Kao, Dina |
| author_facet | Monaghan, Tanya M. Mullish, Benjamin H. Patterson, Jordan Wong, Gane K.S. Marchesi, Julian R. Xu, Huiping Tahseen, Jilani Kao, Dina |
| author_sort | Monaghan, Tanya M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The mechanisms of efficacy for fecal microbiota# transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. Furthermore, the potential implications for host physiology of these FMT-related changes in gut bile acid metabolism are also not well explored. In this study, we investigated the impact of FMT for rCDI upon signalling through the farnesoid X receptor (FXR)-fibroblast growth factor (FGF) pathway. Herein, we identify that in addition to restoration of gut microbiota and bile acid profiles, FMT for rCDI is accompanied by a significant, sustained increase in circulating levels of FGF19 and reduction in FGF21. These FGF changes were associated with weight gain post-FMT, to a level not exceeding the pre-rCDI baseline. Collectively, these data support the hypothesis that the restoration of gut microbial communities by FMT for rCDI is associated with an upregulated FXR-FGF pathway, and highlight the potential systemic effect of FMT. |
| first_indexed | 2025-11-14T20:26:40Z |
| format | Article |
| id | nottingham-53079 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:26:40Z |
| publishDate | 2018 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-530792020-05-04T19:47:12Z https://eprints.nottingham.ac.uk/53079/ Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway Monaghan, Tanya M. Mullish, Benjamin H. Patterson, Jordan Wong, Gane K.S. Marchesi, Julian R. Xu, Huiping Tahseen, Jilani Kao, Dina The mechanisms of efficacy for fecal microbiota# transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. Furthermore, the potential implications for host physiology of these FMT-related changes in gut bile acid metabolism are also not well explored. In this study, we investigated the impact of FMT for rCDI upon signalling through the farnesoid X receptor (FXR)-fibroblast growth factor (FGF) pathway. Herein, we identify that in addition to restoration of gut microbiota and bile acid profiles, FMT for rCDI is accompanied by a significant, sustained increase in circulating levels of FGF19 and reduction in FGF21. These FGF changes were associated with weight gain post-FMT, to a level not exceeding the pre-rCDI baseline. Collectively, these data support the hypothesis that the restoration of gut microbial communities by FMT for rCDI is associated with an upregulated FXR-FGF pathway, and highlight the potential systemic effect of FMT. Taylor & Francis 2018-09-05 Article PeerReviewed Monaghan, Tanya M., Mullish, Benjamin H., Patterson, Jordan, Wong, Gane K.S., Marchesi, Julian R., Xu, Huiping, Tahseen, Jilani and Kao, Dina (2018) Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes . ISSN 1949-0976 microbiota; fecal microbiota transplantation (FMT); recurrent Clostridium difficile infection (rCDI); bile acid metabolism; fibroblast growth factor (FGF)19 https://www.tandfonline.com/doi/full/10.1080/19490976.2018.1506667 doi:1080/19490976.2018.1506667 doi:1080/19490976.2018.1506667 |
| spellingShingle | microbiota; fecal microbiota transplantation (FMT); recurrent Clostridium difficile infection (rCDI); bile acid metabolism; fibroblast growth factor (FGF)19 Monaghan, Tanya M. Mullish, Benjamin H. Patterson, Jordan Wong, Gane K.S. Marchesi, Julian R. Xu, Huiping Tahseen, Jilani Kao, Dina Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway |
| title | Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway |
| title_full | Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway |
| title_fullStr | Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway |
| title_full_unstemmed | Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway |
| title_short | Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway |
| title_sort | effective fecal microbiota transplantation for recurrent clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid x receptor-fibroblast growth factor pathway |
| topic | microbiota; fecal microbiota transplantation (FMT); recurrent Clostridium difficile infection (rCDI); bile acid metabolism; fibroblast growth factor (FGF)19 |
| url | https://eprints.nottingham.ac.uk/53079/ https://eprints.nottingham.ac.uk/53079/ https://eprints.nottingham.ac.uk/53079/ |