Development and analysis of CTG repeat expansion cell lines to understand molecular events in myotonic dystrophy type 1

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Development and analysis of CTG repeat expansion cell lines to understand molecular events in myotonic dystrophy type 1

Myotonic dystrophy type 1 (DM1) is a dominant human neuromuscular disorder caused by a CTG repeat expansion at the 3’ end of the DMPK gene. Pathogenesis of DM1 is linked to a toxic gain of function due to mutant RNA and is manifested by nuclear retention of expanded CUG repeats and aberrant splicing...

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Bibliographic Details
Main Author:	Malik, Naveed Altaf
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2018
Online Access:	https://eprints.nottingham.ac.uk/53025/

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