Endocrine therapy for breast cancer: a model of hormonal manipulation
Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited in combination with established endocrine therapi...
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| Format: | Article |
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Springer
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52982/ |
| _version_ | 1848798853166268416 |
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| author | Johnston, Simon J. Cheung, Kwok-Leung |
| author_facet | Johnston, Simon J. Cheung, Kwok-Leung |
| author_sort | Johnston, Simon J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited in combination with established endocrine therapies to maximise efficacy. However, clinicians must balance this gain against the risk to patients of increased side effects with combination therapies. This article provides a succinct outline of the principles of hormonal manipulation in breast cancer, alongside the key evidence that underpins current clinical practice. As the role of endocrine therapy in breast cancer continues to expand, the challenge is to interpret the data and select the optimal strategy for a given clinical scenario. |
| first_indexed | 2025-11-14T20:26:22Z |
| format | Article |
| id | nottingham-52982 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:26:22Z |
| publishDate | 2018 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-529822020-05-04T19:45:47Z https://eprints.nottingham.ac.uk/52982/ Endocrine therapy for breast cancer: a model of hormonal manipulation Johnston, Simon J. Cheung, Kwok-Leung Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited in combination with established endocrine therapies to maximise efficacy. However, clinicians must balance this gain against the risk to patients of increased side effects with combination therapies. This article provides a succinct outline of the principles of hormonal manipulation in breast cancer, alongside the key evidence that underpins current clinical practice. As the role of endocrine therapy in breast cancer continues to expand, the challenge is to interpret the data and select the optimal strategy for a given clinical scenario. Springer 2018-07-10 Article PeerReviewed Johnston, Simon J. and Cheung, Kwok-Leung (2018) Endocrine therapy for breast cancer: a model of hormonal manipulation. Oncology and Therapy . ISSN 2366-1089 Breast cancer; Combination therapy; Endocrine therapy; Hormone; Oestrogen receptor; Targeted therapy https://link.springer.com/article/10.1007%2Fs40487-018-0062-x doi:10.1007/s40487-018-0062-x doi:10.1007/s40487-018-0062-x |
| spellingShingle | Breast cancer; Combination therapy; Endocrine therapy; Hormone; Oestrogen receptor; Targeted therapy Johnston, Simon J. Cheung, Kwok-Leung Endocrine therapy for breast cancer: a model of hormonal manipulation |
| title | Endocrine therapy for breast cancer: a model of hormonal manipulation |
| title_full | Endocrine therapy for breast cancer: a model of hormonal manipulation |
| title_fullStr | Endocrine therapy for breast cancer: a model of hormonal manipulation |
| title_full_unstemmed | Endocrine therapy for breast cancer: a model of hormonal manipulation |
| title_short | Endocrine therapy for breast cancer: a model of hormonal manipulation |
| title_sort | endocrine therapy for breast cancer: a model of hormonal manipulation |
| topic | Breast cancer; Combination therapy; Endocrine therapy; Hormone; Oestrogen receptor; Targeted therapy |
| url | https://eprints.nottingham.ac.uk/52982/ https://eprints.nottingham.ac.uk/52982/ https://eprints.nottingham.ac.uk/52982/ |