Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

QR Code

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

The intestinal lymphatic system plays an important role in the pathophysiology of multiple diseases including lymphomas, cancer metastasis, autoimmune diseases, and human immunodeficiency virus (HIV) infection. It is thus an important compartment for delivery of drugs in order to treat diseases asso...

Full description

Bibliographic Details
Main Authors:	Lee, Jong Bong, Zgair, Atheer, Malec, Jed, Kim, Tae Hwan, Kim, Min Gi, Ali, Joseph, Qin, Chaolong, Feng, Wanshan, Chiang, Manting, Gao, Xizhe, Voronin, Gregory, Garces, Aimie, Lau, Chun Long, Chan, Ting-Hoi, Hume, Amy, McIntosh, Tecashanell M., Soukarieh, Fadi, Al-Hayali, Mohammed, Cipolla, Elena, Collins, Hilary M., Heery, David M., Shin, Beom Soo, Yoo, Sun Dong, Kagan, Leonid, Stocks, Michael J., Bradshaw, Tracey D., Fischer, Peter M., Gershkovich, Pavel
Format:	Article
Published:	Elsevier 2018
Subjects:	Lymphatic transport; Prodrugs; Bexarotene; Retinoic acid; Chylomicron; Activated esters
Online Access:	https://eprints.nottingham.ac.uk/52980/

Similar Items

Synthesis and Evaluation of Lung Tissue Retentive Prodrugs
by: Ayre, Jack
Published: (2022)

Biological Evaluation of Synergistic Drug Combinations, Design and Synthesis of Potent and Selective PI3K Inhibitors and the Design of Bifunctional Ligands Incorporating Pictilisib & Ceritinib for the Treatment of EML4-ALK Positive Lung Cancer
by: Garces, Aimie E.
Published: (2019)

Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma
by: Lee, Jong Bong, et al.
Published: (2017)

Engineering a Mastoparan Peptide Concatemer Prodrug From CircRNA for Cancer Therapy
by: Grewcock, Declan
Published: (2023)

Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity
by: Taha, Dhiaa A., et al.
Published: (2017)

Using high-throughput approaches to unveil sporulation and germination mechanisms in Clostridium sporogenes
by: Mesquita Rodrigues, Raquel
Published: (2020)

Influence of acid-base imbalance and hyperlipidaemia on statin-induced myotoxicity
by: Taha, Dhiaa A.
Published: (2017)

Post-prandial lipid metabolism, lipid-modulating agents and cerebrovascular integrity: Implications for dementia risk
by: Pallebage-Gamarallage, Menuka, et al.
Published: (2010)

Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding
by: Purdie, Laura, et al.
Published: (2018)

Targeting Lopinavir to the Mesenteric Lymphatic System by Lipophilic Ester Prodrug Approach for Improved Treatment of HIV/AIDS
by: Qin, Chaolong
Published: (2021)

The proliferation and differentiation responses of adult mouse neural stem cells in vitro
by: Chou, Robert Chang-Chih
Published: (2015)

Anticancer effects of combined gamma-tocotrienol and 13-cis retinoic acid against neuroblastoma cells and xenografts
by: Ch'ng, Qin Ting
Published: (2021)

Targeting DNA repair and hypoxia to improve radioresponse in breast cancer
by: Aiyappa, Radhika
Published: (2020)

Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities
by: Ghawanmeh, Abdullah A., et al.
Published: (2018)

CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation
by: Quintero, Cynthia M., et al.
Published: (2018)

PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma
by: Luo, Tian, et al.
Published: (2016)

Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
by: Li, Wenlong, et al.
Published: (2017)

Stimuli-responsive prodrug chemistries for drug delivery
by: Taresco, Vincenzo, et al.
Published: (2018)

Self-assembling antitumour prodrugs for localised drug delivery
by: Citossi, Francesca
Published: (2016)

Encapsulation of metal complex into apoferritin for drug delivery and prodrug activation
by: Cassioli, Maria Letizia
Published: (2023)

The development of molecular tools for the expression of prodrug converting enzymes in Clostridium sporogenes
by: Pennington, Oliver John
Published: (2006)

Delivery of imiquimod to intestinal lymph nodes following oral administration
by: Chen, Haojie
Published: (2025)

Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays
by: Lee, Jong Bong, et al.
Published: (2017)

Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres
by: Popat, A., et al.
Published: (2012)

Oral lipid-based drug delivery approaches to improve the intestinal lymphatic transport and systemic bioavailability of a highly lipophilic drug cannabidiol
by: Feng, Wanshan
Published: (2022)

Development of a liquid chromatography/mass spectrometry methodology to separate, detect, characterize and quantify PEG-resveratrol prodrugs and the conjugation reaction precursors and intermediates
by: Basavaraj, S., et al.
Published: (2011)

Development of cordycepin formulations for preclinical and clinical studies
by: Lee, Jong Bong, et al.
Published: (2017)

Design, synthesis, and biological evaluation of NAD(P)H: quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation
by: Xu, Shengtao, et al.
Published: (2017)

Intestinal lymphatic transport of cannabinoids: implications for people with autoimmune diseases and immunocompromised individuals
by: Zgair, Atheer
Published: (2017)

Characterisation of anticancer properties of a novel and naturally isolated bisindole alkaloid, conofolidine
by: Al-Hayali, Mohammed Zuhair Khaleel
Published: (2018)

Accessing inpatient rehabilitation after acute severe stroke: Age, mobility, prestroke function and hospital unit are associated with discharge to inpatient rehabilitation
by: Hakkennes, Sharon, et al.
Published: (2012)

Queering orientations: towards a queer phenomenology of queer tango
by: Purser, Aimie
Published: (2017)

The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets
by: Canobbio, I., et al.
Published: (2015)

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines
by: Zgair, Atheer, et al.
Published: (2016)

Work culture in CTRM Aero Composites: individualism vs collectivism / Aimie Asfarinna Azman
by: Azman, Aimie Asfarinna
Published: (2011)

Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited
by: Constantinescu, Cris S., et al.
Published: (2018)

Exploring the embodied basis of being through Merleau-Ponty and dance: a conversation between philosophy and practice
by: Purser, Aimie Christianne Elizabeth.
Published: (2008)

Dancing intercorporeality: a health humanities perspective on dance as a healing art
by: Purser, Aimie Christianne Elizabeth.
Published: (2017)

Dancing like a girl: physical competence and emotional vulnerability in professional contemporary dance
by: Purser, Aimie Christianne Elizabeth.
Published: (2017)

Intercorporeality: connectedness and creative collaboration in the embodied practice of dance
by: Purser, Aimie Christianne Elizabeth.
Published: (2016)