Carbene in cupredoxin protein scaffolds: replacement of a histidine ligand in the active site substantially alters copper redox properties

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Carbene in cupredoxin protein scaffolds: replacement of a histidine ligand in the active site substantially alters copper redox properties

N-heterocyclic carbene (NHC) ligands have had a major impact in homogeneous catalysis, however, their potential role in biological systems is essentially unexplored. Here we replaced a copper-coordinating histidine (His) in the active site of azurin with exogenous dimethyl-imidazolylidene; this NHC...

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Bibliographic Details
Main Authors:	Planchestainer, Matteo, Segaud, Nathalie, Shanmugam, Muralidharan, McMaster, Jonathan, Paradisi, Francesca, Albrecht, Martin
Format:	Article
Published:	Wiley-VCH Verlag 2018
Subjects:	metalloenyzme histidine bonding mode N-heterocyclic carbene electron transfer processes
Online Access:	https://eprints.nottingham.ac.uk/52943/

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