Sumoylation and phosphorylation: hidden and overt links
Post-translational modifications are essential mediators between stimuli from development or the environment and adaptive transcriptional patterns. Recent data allow a first glimpse at how two modifications, phosphorylation and sumoylation, act interdependently to modulate stress responses. In parti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Oxford University Press
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52927/ |
| _version_ | 1848798841958039552 |
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| author | Tomanov, Konstantin Nukarinen, Ella Vicente, Jorge Mendiondo, Guillermina M. Winter, Nikola Nehlin, Lilian Weckwerth, Wolfram Holdsworth, Michael J. Teige, Markus Bachmair, Andreas |
| author_facet | Tomanov, Konstantin Nukarinen, Ella Vicente, Jorge Mendiondo, Guillermina M. Winter, Nikola Nehlin, Lilian Weckwerth, Wolfram Holdsworth, Michael J. Teige, Markus Bachmair, Andreas |
| author_sort | Tomanov, Konstantin |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Post-translational modifications are essential mediators between stimuli from development or the environment and adaptive transcriptional patterns. Recent data allow a first glimpse at how two modifications, phosphorylation and sumoylation, act interdependently to modulate stress responses. In particular, many components of the SUMO conjugation system are phosphoproteins, and some regulators and enzymes of protein phosphorylation can be sumoylated. Equally important, however, a number of proteins can be subject to both modifications. These substrates also have the capacity to connect stimuli transmitted via sumoylation with those transmitted via phosphorylation. As a prime example, we review data suggesting that nitrate reductase is a hub that integrates cues from these two modifications. Powerful proteomics approaches allowed the identification of additional common substrates, paving the way for studies to understand, on a broader basis, the cross-talk of phosphorylation with sumoylation and how it contributes to plant growth. |
| first_indexed | 2025-11-14T20:26:11Z |
| format | Article |
| id | nottingham-52927 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:26:11Z |
| publishDate | 2018 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-529272020-05-04T19:37:44Z https://eprints.nottingham.ac.uk/52927/ Sumoylation and phosphorylation: hidden and overt links Tomanov, Konstantin Nukarinen, Ella Vicente, Jorge Mendiondo, Guillermina M. Winter, Nikola Nehlin, Lilian Weckwerth, Wolfram Holdsworth, Michael J. Teige, Markus Bachmair, Andreas Post-translational modifications are essential mediators between stimuli from development or the environment and adaptive transcriptional patterns. Recent data allow a first glimpse at how two modifications, phosphorylation and sumoylation, act interdependently to modulate stress responses. In particular, many components of the SUMO conjugation system are phosphoproteins, and some regulators and enzymes of protein phosphorylation can be sumoylated. Equally important, however, a number of proteins can be subject to both modifications. These substrates also have the capacity to connect stimuli transmitted via sumoylation with those transmitted via phosphorylation. As a prime example, we review data suggesting that nitrate reductase is a hub that integrates cues from these two modifications. Powerful proteomics approaches allowed the identification of additional common substrates, paving the way for studies to understand, on a broader basis, the cross-talk of phosphorylation with sumoylation and how it contributes to plant growth. Oxford University Press 2018-05-25 Article PeerReviewed Tomanov, Konstantin, Nukarinen, Ella, Vicente, Jorge, Mendiondo, Guillermina M., Winter, Nikola, Nehlin, Lilian, Weckwerth, Wolfram, Holdsworth, Michael J., Teige, Markus and Bachmair, Andreas (2018) Sumoylation and phosphorylation: hidden and overt links. Journal of Experimental Botany . ISSN 1460-2431 http://dx.doi.org/10.1093/jxb/ery167 10.1093/jxb/ery167 10.1093/jxb/ery167 10.1093/jxb/ery167 |
| spellingShingle | Tomanov, Konstantin Nukarinen, Ella Vicente, Jorge Mendiondo, Guillermina M. Winter, Nikola Nehlin, Lilian Weckwerth, Wolfram Holdsworth, Michael J. Teige, Markus Bachmair, Andreas Sumoylation and phosphorylation: hidden and overt links |
| title | Sumoylation and phosphorylation: hidden and overt links |
| title_full | Sumoylation and phosphorylation: hidden and overt links |
| title_fullStr | Sumoylation and phosphorylation: hidden and overt links |
| title_full_unstemmed | Sumoylation and phosphorylation: hidden and overt links |
| title_short | Sumoylation and phosphorylation: hidden and overt links |
| title_sort | sumoylation and phosphorylation: hidden and overt links |
| url | https://eprints.nottingham.ac.uk/52927/ https://eprints.nottingham.ac.uk/52927/ https://eprints.nottingham.ac.uk/52927/ |